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Targeting neuronal maturation to promote axon regeneration following spinal cord injury
https://braincanada.ca/funded-grants/targeting-neuronal-maturation-to-promote-axon-regeneration-following-spinal-cord-injurySpinal cord injury leads to permanent and severe paralysis and loss of sensation. Project Overview Spinal cord injury leads to permanent and severe paralysis and loss of sensation. The principal reason for this is that nerve cells connecting the brain with the rest of the body lose the capacity to...
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Targeting the immune suppressive microenvironment in histone 3-mutant high-grade gliomas
https://braincanada.ca/funded-grants/targeting-the-immune-suppressive-microenvironment-in-histone-3-mutant-high-grade-gliomasThe immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. Project Overview The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. By exploring the role of these cells...
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Targeting the microbiota-gut-brain axis with diet and exercise interventions in individuals with subjective cognitivedecline
https://braincanada.ca/funded-grants/targeting-the-microbiota-gut-brain-axis-with-diet-and-exercise-interventions-in-individuals-with-subjective-cognitivedeclineIndividuals with or at increased risk of Alzheimer’s disease (AD) have an altered community of microbes(microbiome) within the intestinal tract. Project Overview Individuals with or at increased risk of Alzheimer’s disease (AD) have an altered community of microbes(microbiome) within the intestinal...
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Targeting the Retrosplenial Cortex to Promote Cognition in a Mouse Model of Alzheimer’s Disease
https://braincanada.ca/funded-grants/targeting-the-retrosplenial-cortex-to-promote-cognition-in-a-mouse-model-of-alzheimer-s-diseaseAlzheimer’s disease is a devastating disorder that slowly destroys brain function, leading to memory loss and cognitive decline. Despite decades of research, current treatments offer only modest benefit, and most are less effective in women than in men. Project Overview Alzheimer’s disease is a...
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Targeting the Synaptic Pathway in Neurodevelopmental and Psychiatric Disorders
https://braincanada.ca/funded-grants/targeting-the-synaptic-pathway-in-neurodevelopmental-and-psychiatric-disordersAutism spectrum disorders are neurodevelopmental disorders characterized by deficits in social interaction, poor communication, and restricted, stereotyped patterns of behavior. Project Overview Autism spectrum disorders are neurodevelopmental disorders characterized by deficits in social...
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Targeting the telomere maintenance pathway for cancer diagnostics and therapeutics.
https://braincanada.ca/funded-grants/targeting-the-telomere-maintenance-pathway-for-cancer-diagnostics-and-therapeuticsCancer can exhibit relentless growth and relapse because of the enhanced protection of its chromosome ends. Project Overview Cancer can exhibit relentless growth and relapse because of the enhanced protection of its chromosome ends. Dr. Uri Tabori is a world expert in telomeres – the protective...
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Targeting the USP19 deubiquitinating enzyme for the treatment of Alzheimer’s disease
https://braincanada.ca/funded-grants/targeting-the-usp19-deubiquitinating-enzyme-for-the-treatment-of-alzheimer-s-diseaseAlzheimer’s disease progresses over time due to the spreading of aggregates of tau protein and amyloid protein from unaffected to affected regions of the brain. Project Overview Alzheimer’s disease progresses over time due to the spreading of aggregates of tau protein and amyloid protein from...
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Teaching Adolescents with type 1 Diabetes Self-compassion (TADS) to reduce diabetes distress: A randomized controlled trial
https://braincanada.ca/funded-grants/teaching-adolescents-with-type-1-diabetes-self-compassion-tads-to-reduce-diabetes-distress-a-randomized-controlled-trialSelf-compassion is a practice that involves acting the same way towards yourself as you would with friends and loved ones, and that you are kind and understanding towards yourself. Project Overview Self-compassion is a practice that involves acting the same way towards yourself as you would with...
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Team detects signs of early autism in at-risk infants
https://braincanada.ca/about/news-updates/team-detects-signs-of-early-autism-in-at-risk-infantsAutism is often perceived on a linear scale, or spectrum. Those touched by the condition know this is an over-simplification. A multi-dimensional structure influenced by differences in language, motor skills, executive functioning and sensory perceptions would perhaps be a better way to describe...
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TECC-T1D3: Technology-enabled Comprehensive Care for young adults with Type 1 Diabetes and Diabetes Distress
https://braincanada.ca/funded-grants/tecc-t1d3-technology-enabled-comprehensive-care-for-young-adults-with-type-1-diabetes-and-diabetes-distressDiabetes distress, the negative emotional feelings resulting from living with diabetes and the burden of selfmanagement, is a very common challenge for people living with type 1 diabetes affecting approximately 40%. Project Overview Diabetes distress, the negative emotional feelings resulting from...