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Therapeutic breakthroughs in Huntington Disease (HD), Alzheimer’s Disease (AD), Parkinson Disease (PD), and other neurodegenerative disorders have been accelerated by access to generously donated human samples. The HD Biobank at the University of British Columbia focuses on neurodegenerative...

Dr. Christopher West (left) and members of his research team. At the University of British Columbia, Dr. Christopher West and his team are exploring the heart and brain connection in spinal cord injury. With the support of Brain Canada and the Heart and Stroke Foundation, through an Emerging...

It was with much sadness that we learned of the passing of The Hon. Michael H. Wilson. Michael was a founder and past Chair of Brain Canada, and remained an inspiration and a passionate champion of this organization through the years.  Canada has lost one of our greatest citizens; he will be...

The abnormal accumulation of misfolded proteins and aggregates is the hallmark of multiple forms of ALS and other neurodegenerative diseases. Project Overview The abnormal accumulation of misfolded proteins and aggregates is the hallmark of multiple forms of ALS and other neurodegenerative...

Women are more likely than men to be diagnosed with Alzheimer’s disease, and they also tend to develop greater declines in memory and other cognitive functions. Project Overview Women are more likely than men to be diagnosed with Alzheimer’s disease, and they also tend to develop greater declines...

Thanks to advances in cancer treatments, more than 80% of children treated for brain tumors now survive at least five years after their diagnosis. Project Overview Thanks to advances in cancer treatments, more than 80% of children treated for brain tumors now survive at least five years after their...

After a stroke that weakened his left side, Stéphane Rouleau says he slept nearly nonstop for almost a year. Now, he is meticulous about nutrition and fitness to support his recovery. Stéphane Rouleau used to be an ultramarathoner and a cross-country mountain biker with Olympic potential. He’d had...

Declining cognitive activity is associated with a wide-variety of neurodegenerative disorders, brain injuries as well as with normal aging despite any clear pathological condition. Project Overview Declining cognitive activity is associated with a wide-variety of neurodegenerative disorders, brain...

The Huntington disease (HD) mutation produces a pathogenic mutant HTT (mHTT) protein with an elongated polyglutamine tract. Presence of mHTT disrupts diverse cellular pathways, leading to adverse molecular phenotypes including inflammation, impaired synaptic transmission, and eventually...