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Dr. Eran Hornstein (left) with Dr. Angela Genge Clinical trial evaluates the drug enoxacin as a therapeutic option for ALS, add-on studies supported by Discovery Grant "Ideally, one day, the results of our work will mean that we will be able to provide a new remedy for patients suffering from...

Regardless of disease etiology, ~97% of ALS patients display TDP-43 pathology. TDP-43 is an RNA-binding protein that is involved in the cellular stress response. Following a stressor, TDP-43 translocates to the cytosol and is thought to be protective. However, with chronic stress and/or ALS-relevant...

Dr. Martin Duennwald (left) and Dr. Sali Farhan Understanding how mutation in “first responder” gene can lead to neurodegeneration in ALS "It’s been such an honor to be a part of this community. We are scientists, but we’re also humans, and we know how devastating this disease is. As researchers,...

When Dr. Renée Douville found out she had been awarded one of the 2022 ALS Canada–Brain Canada Discovery Grants, she was excited. Very excited. Could this new mouse model help to understand the potential role of retroviruses in ALS and lead to new treatments? Award: $125,000 Collaborators: Dr. Jody...

We make memories and retrieve memories all the time, but there’s a lot we don’t understand about how the brain performs these essential functions. By Alison Palmer We make memories and retrieve memories all the time, but there’s a lot we don’t understand about how the brain performs these essential...

Believe them when they say they can’t do something, are having difficulty, or tell you about certain symptoms they’re experiencing. Avoid responding in ways that show suspicion or downplay their experience, such as “You don’t look injured,” “Look on the bright side,” “You must be fully recovered,”...

Our brains are built by neural stem cells (NSCs), which produce all the neurons and other specialized cells that form the brain and execute its functions. Project Overview Our brains are built by neural stem cells (NSCs), which produce all the neurons and other specialized cells that form the brain...

Studies of genetic disorders are limited because of the lack of appropriate tissue samples from patients. Project Overview Studies of genetic disorders are limited because of the lack of appropriate tissue samples from patients. A promising avenue to overcome this deficit is the recently described...

The purpose of this project is to develop promoters. Promoters are pieces of DNA, which act as switches to turn genes on and off. Project Overview The purpose of this project is to develop promoters. Promoters are pieces of DNA, which act as switches to turn genes on and off. Such promoters are...

The CIFAR Humans & the Microbiome program brings together 21 researchers to examine what consciousness is and how it comes about. Project Overview The CIFAR Humans & the Microbiome program brings together 21 researchers to examine what consciousness is and how it comes about. The program is part of...