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It is not known why ALS is a rapidly progressing disease. Project Overview It is not known why ALS is a rapidly progressing disease. The discovery that the accumulation of TAR DNA-binding protein 43 kDa (TDP-43) is a pathological hallmark of sporadic ALS and a subset of frontotemporal lobar...

The mammalian brain comprises millions of neurons that constantly communicate through connections known as synapses. Project Overview The mammalian brain comprises millions of neurons that constantly communicate through connections known as synapses. Synapses are plastic and adapt their...

In Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. Project Overview In Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. There are no therapeutic interventions that sufficiently prevent or...

Amyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s movement. Project Overview Amyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s...

Psychedelic drugs, known for their profound effects on perception, are showing promise as rapid and long-lasting treatments for depression. Project Overview Psychedelic drugs, known for their profound effects on perception, are showing promise as rapid and long-lasting treatments for depression....

"Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment and cognitive decline." Project Overview “Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment and...

The formation of our memories is a behaviour that encapsulates both long-and-short time scales. Project Overview The formation of our memories is a behaviour that encapsulates both long-and-short time scales. On the short time-scale, memories are initially formed in the hippocampus through the...

TDP-43 (transactive response DNA-binding protein 43) is one of the few genes highly associated with ALS (amyotrophic lateral sclerosis). Project Overview TDP-43 (transactive response DNA-binding protein 43) is one of the few genes highly associated with ALS (amyotrophic lateral sclerosis). Although...

Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly. Project Overview Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function...

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that damages nerve cells controlling movement, and many patients also experience major changes in how their bodies use energy. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that damages nerve cells controlling...