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Identification of novel genes causing intracranial aneurysms
https://braincanada.ca/funded-grants/identification-of-novel-genes-causing-intracranial-aneurysmsStroke is the leading cause of disability among adults and one of the three leading causes of death in North America. Project Overview Stroke is the leading cause of disability among adults and one of the three leading causes of death in North America. Intracranial aneurysm (IA) is one of the main...
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Identification of Protein Interactions That Regulate FUS Mislocalization and Aggregation in ALS
https://braincanada.ca/funded-grants/identification-of-protein-interactions-that-regulate-fus-mislocalization-and-aggregation-in-alsAmyotrophic lateral sclerosis (ALS) is a debilitating and terminal disease. Project Overview Amyotrophic lateral sclerosis (ALS) is a debilitating and terminal disease. A common hallmark of its familial and sporadic forms is the accumulation of insoluble protein aggregates in the cytoplasm of motor...
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Identification of the Neural Circuitry of Persistent Depressive Symptoms in First-Episode Schizophrenia: From Biomarkers to Predictive Imaging
https://braincanada.ca/funded-grants/identification-of-the-neural-circuitry-of-persistent-depressive-symptoms-in-first-episode-schizophrenia-from-biomarkers-to-predictive-imagingPeople with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. Project Overview People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. These...
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Identifying Proteogenomic Signatures Of Smoldering Lesions in Multiple Sclerosis
https://braincanada.ca/funded-grants/identifying-proteogenomic-signatures-of-smoldering-lesions-in-multiple-sclerosisMultiple sclerosis (MS) is the most common cause of non-traumatic neurological disability, affecting 1 in 400 Canadian adults. Project Overview Multiple sclerosis (MS) is the most common cause of non-traumatic neurological disability, affecting 1 in 400 Canadian adults. It occurs when the immune...
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Identifying the cell-type specific transcriptional program by Npas4 in motor learning
https://braincanada.ca/funded-grants/identifying-the-cell-type-specific-transcriptional-program-by-npas4-in-motor-learningThe primary motor cortex in the brain is responsible for voluntary movement. It has also been proposed to be one of the sites for motor memory formation and storage. Project Overview The primary motor cortex in the brain is responsible for voluntary movement. It has also been proposed to be one of...
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Igniting Hope fosters connection, learning and the promise of a better future for youth mental health in Canada
https://braincanada.ca/about/news-updates/igniting-hope-fosters-connection-learning-and-the-promise-of-a-better-future-for-youth-mental-health-in-canadaMore than 70 youth leaders, advocates, clinicians, researchers, policymakers, and stakeholders came together in Toronto on November 15 for an open exchange on youth mental health, hosted by Brain Canada, with support from RBC. More than 70 youth leaders, advocates, clinicians, researchers,...
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Illuminating the Stimulated Brain: Decoding Real-Time Transcranial Electrical Stimulation Effects in Cognitive Aging with Functional Near Infrared Spectroscopy
https://braincanada.ca/funded-grants/illuminating-the-stimulated-brain-decoding-real-time-transcranial-electrical-stimulation-effects-in-cognitive-aging-with-functional-near-infrared-spectroscopyAs we age, the brain naturally changes, sometimes making it harder to remember things, stay focused, or think as quickly as we used to. Despite these changes, the aging brain still has an important ability called plasticity: it can adapt and reorganize itself. Harnessing this ability may help us...
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Imaging a New ALS Biomarker in the Eye
https://braincanada.ca/funded-grants/imaging-a-new-als-biomarker-in-the-eyeCurrent biomarkers of ALS used by clinicians to help care for ALS patients have many drawbacks that may include cost, accessibility, and invasiveness of procedures. Project Overview Current biomarkers of ALS used by clinicians to help care for ALS patients have many drawbacks that may include cost,...
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Imaging Endocannabinoid Signalling in Individuals with Cocaine Addiction
https://braincanada.ca/funded-grants/imaging-endocannabinoid-signalling-in-individuals-with-cocaine-addictionCocaine is a highly addictive stimulant drug. Approximately 10% of Canadians aged 20-24 report current cocaine use. Project Overview Cocaine is a highly addictive stimulant drug. Approximately 10% of Canadians aged 20-24 report current cocaine use. Demand for the drug is growing and rates of...
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Immunotherapy as a targeted low-impact treatment of paediatric brain cancers
https://braincanada.ca/funded-grants/immunotherapy-as-a-targeted-low-impact-treatment-of-paediatric-brain-cancersThe existing treatment regimens for children with ependymomas are generally not successful and if successful survivors are left with considerable disabilities including severely diminished IQ, focal neurological and language deficits, and endocrine deficiencies. Project Overview The existing...