740 results found
Transforming research on chronic pain
Project Overview
Pain affects millions of people worldwide and has a profound negative effect on quality of life. Untreated pain is the most common cause of disability that impairs life. Acute pain is a normal sensation triggered by the nervous system to alert the body to an injury. Chronic pain, on the…
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See the project and researchersMitochondrial dysfunction and neuronal demise: Insights provided by Parkinson’s disease genes
Project Overview
Converging research efforts have recently identified five genes that are associated with familial Parkinson’s Disease (PD), a condition associated with severe motor dysfunction and loss of dopamine-producing cells in the brain. These genes include α-synuclein, Parkin, DJ-1, Pink1, LRRK2. It is striking that all of them have been linked directly…
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See the project and researchersNovel therapeutic strategies to repair brain abnormalities in psychiatric disorders
Project Overview
Communication between brain cells is essential for normal brain function. Healthy brain cells are controlled through chemical messengers that stimulate or inhibit brain activity. Current theories indicate that psychiatric disorders such as addiction, schizophrenia, autism and mental retardation evolve from an imbalance of these chemical messengers leading to a disruption…
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See the project and researchersHarnessing beneficial aspects of neuroinflammation for regenerating the central nervous system
Project Overview
This research project, led by Dr. V. Wee Yong from the University of Calgary, focused on the immune system, which is comprised of two major components, the innate and adaptive systems. Innate immunity is the first immune component to sense and respond to an injury. Indeed, a well-regulated innate immune…
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See the project and researchersProject MinE
Project Overview
Project MinE is a multi-national initiative with currently participating countries. The goal is to create a database of whole genome sequences for 15,000 people with ALS and 7,500 control subject. This will provide a global resource of human data that will enable scientists worldwide to understand the genetic signature that…