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8 results found

Stress granules: neuroprotective or neurotoxic in ALS pathogenesis?

ALS is a devastatingly fatal neurodegenerative disease with patients losing their ability to walk, talk, eat, and interact with their loved ones.

Project ongoing See Project & Researchers
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025

Relevance of stress granule dynamics to ALS pathogenesis in vivo

Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective treatment.

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2024

Deepening our understanding of G3BP1 and its paralog G3BP2 to facilitate accurate therapeutic development for ALS/FTD

While significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt ALS disease progression has remained elusive.

Project ongoing See Project & Researchers
Grant type
Team grants
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2023

Investigating the neuronal function of a novel HNRNPA1 variant

While significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt amyotrophic lateral sclerosis (ALS) progression has remained elusive.

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2022

Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS

Amyotrophic lateral sclerosis (ALS) is a terminal disease that paralyzes people because the brain is no longer able to communicate with the muscles that we are typically able to move at will.

Project ongoing See Project & Researchers
Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
2019 Platform Support Grants
Province
Alberta
Start Date
2021

Douglas-Bell Canada Brain Bank, an essential platform for brain research in Canada

The Douglas-Bell Canada Brain Bank (DBCBB) houses and manages over 3,000 brains, as well as a large relational database containing demographic, clinical and developmental histories from the donors.

Project completed See Project & Researchers
Grant type
Platform grants
Area of Research
Mental Health
Competition
2014 Platform Grants
Province
Québec
Start Date
2015

Regulation of the stress granule proteome and transcriptome by TDP-43 in ALS: biomarkers and therapeutic targets

When cells are under stress, one of the reactions is to form tiny clumps called stress granules that protect important genetic information while protective mechanisms kick in.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Québec
Start Date
2015

Misfolded SOD1 in ALS pathogenesis

The first genetic cause of ALS to be discovered (in 1993) encoded a mutation in protein called superoxide dismutase 1 (SOD1).

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2015