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The aims of the proposal were to examine the mechanism of how dopamine neurons degenerate in Parkinson (PD) animal models. Project Overview The aims of the proposal were to examine the mechanism of how dopamine neurons degenerate in Parkinson (PD) animal models. The work was centered on three...

The human brain is vulnerable to too much of mTOR signaling, An important neuronal pathway regulating neuronal development and activity. Project Overview The human brain is vulnerable to too much of mTOR signaling, An important neuronal pathway regulating neuronal development and activity. We study...

Addiction is a massive issue that spans generations and cultures. Project Overview Addiction is a massive issue that spans generations and cultures. Understanding and learning to help those suffering from addiction should continue to be a high- priority topic. Whether it’s looking to the past for...

We identified changes in the gene called IRF2BPL (Interferon Regulatory Factor 2 Binding Protein Like) as the cause of a severe brain disorder in children called NEDAMSS (Neurodevelopmental disorder with abnormal movements, loss of speech and seizures). Project Overview We identified changes in the...

Cannabis is one of the most commonly used recreational substances in Canada, yet its effects on brain blood flow remain poorly understood. Project Overview Cannabis is one of the most commonly used recreational substances in Canada, yet its effects on brain blood flow remain poorly understood....

The brain is vulnerable to many disorders that can strike at every stage of life. Project Overview The brain is vulnerable to many disorders that can strike at every stage of life. Bipolar disorder (BD) is a chronic and disabling neuropsychiatric condition that affects 1 in 50 Canadian adults. Like...

Ms. Shearer’s study is the first to address the knowledge gap related to multiple short-term pain fluctuations, the temporal association of pain trajectories on well-being, and the experiential assessment and data triangulation of pain trajectories and their impact, all using self-reported data....

Hong Lu is one of two recipients of Brain Canada’s 2021 Shireen and Edna Marcus Excellence Awards, to assist in his research into the causes and potential treatments of autism University of British Columbia PhD candidate Hong Lu has been awarded the Shireen and Edna Marcus Award for his work in...

There are many neurological and neuropsychiatric diseases that affect men and women differently, but we don’t have a clear picture as to why. One factor that may be important is the influence of hormones during puberty, which can change the way in which genes are used by brain cells, affecting their...

Periodontitis, a chronic oral inflammatory disease-causing tissue damage, bone deterioration and tooth loss, has been linked to Alzheimer’s disease. Project Overview Periodontitis, a chronic oral inflammatory disease-causing tissue damage, bone deterioration and tooth loss, has been linked to...