Search

Amyotrophic Lateral Sclerosis (ALS) is a progressive disease that destroys the motor neurons needed for movement, speech, and breathing, but new research shows that other spinal cord cells called interneurons may be affected even earlier. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a...

For this project, Dr. Park will examine how abnormalities in RNA binding proteins (RBPs) – in particular, one called Matrin 3 (MATR3) – can lead to ALS. MATR3 was discovered to be a genetic cause of ALS in 2014 and has yet to be studied in any detail. Project Overview For this project, Dr. Park...

The key neuropathology underlying ASDs is abnormal neuronal communication as a result of altered synapse formation, function and plasticity. Project Overview The key neuropathology underlying ASDs is abnormal neuronal communication as a result of altered synapse formation, function and plasticity....

A group of viruses called enteroviruses can cause a variety of infectious illnesses that are usually mild with symptoms that may include fever, respiratory distress, flu-like muscle aches and rashes. Project Overview A group of viruses called enteroviruses can cause a variety of infectious...

A significant proportion of critically ill children experience delirium, a form of brain dysfunction associated with adverse outcomes. Project Overview A significant proportion of critically ill children experience delirium, a form of brain dysfunction associated with adverse outcomes. In children,...

Retina-based optogenetic therapy is a promising approach to restore vision to individuals suffering from retinal degeneration. Project Overview Retina-based optogenetic therapy is a promising approach to restore vision to individuals suffering from retinal degeneration. After photoreceptor...

The objective of our project is to investigate if women with carotid stenosis (CAS) have impaired cerebral blood flow (CBF) regulation in different regions of their brain. Project Overview The objective of our project is to investigate if women with carotid stenosis (CAS) have impaired cerebral...

In late 2011, a landmark discovery was made which identified that abnormalities (mutation) in a gene called C9ORF72 were responsible for the highest percentage of hereditary ALS and frontotemporal dementia cases. Project Overview In late 2011, a landmark discovery was made which identified that...

A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. Project Overview A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. We have identified a process called “SUMOylation” that...

The human brain is made up of neural circuits that are thought to underlie all brain function. Project Overview The human brain is made up of neural circuits that are thought to underlie all brain function. These circuits are made up of contact points called synapses where individual nerve cells...