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Charlotte Manser is turning her grief into hope
https://braincanada.ca/about/news-updates/charlotte-manser-is-turning-her-grief-into-hopeMeet the students behind the 2022 ALS Canada – Brain Canada Trainee Awards. Charlotte Manser is the recipient of a $75,000 ALS Canada – Brain Canada 2022 Trainee Award. As a PhD student at the University of Ottawa, she investigates how ALS-linked genes might contribute to the loss of normal stress...
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Cholinergic & noradrenergic contributions to presymptomatic AD progression
https://braincanada.ca/funded-grants/cholinergic-noradrenergic-contributions-to-presymptomatic-ad-progressionThe development of approaches to aid early detection of the transition from healthy aging to mild cognitive impairment and Alzheimer’s disease (AD) is critically important for developing targeted strategies to halt or slow disease progression. Project Overview The development of approaches to aid...
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Circadian control of microglial activation in chronic pain states
https://braincanada.ca/funded-grants/circadian-control-of-microglial-activation-in-chronic-pain-statesCircadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body temperature control the best known examples. Project Overview Circadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body...
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Clinical trial to help children recover from brain cancer
https://braincanada.ca/about/news-updates/clinical-trial-to-help-children-recover-from-brain-cancerA pilot project funded through a W. Garfield Weston Foundation – Brain Canada Multi-Investigator Research Initiative (MIRI) grant in 2012 proved the feasibility of repairing brain injuries in children caused by radiation treatment. Now, the team is running a phase three clinical trial to test the...
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Closed-loop deep brain stimulation using chronic intracranial cortical sensing to inform subcortical stimulation delivery
https://braincanada.ca/funded-grants/closed-loop-deep-brain-stimulation-using-chronic-intracranial-cortical-sensing-to-inform-subcortical-stimulation-deliveryMany people with Parkinson’s disease have trouble with freezing of gait (FoG), a symptom that causes them to stop walking unexpectedly and makes them more likely to fall. Project Overview Many people with Parkinson’s disease have trouble with freezing of gait (FoG), a symptom that causes them to...
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Closing the gap: Two national networks secure $10M in funding for women’s heart and brain health research
https://braincanada.ca/about/news-updates/closing-the-gap-two-national-networks-secure-10m-in-funding-for-women-s-heart-and-brain-health-researchResearch will shed light on how to reduce and prevent death and serious illness from heart conditions and stroke in women. Women experience distinct heart disease and stroke symptoms and risk factors that remain under-researched and misunderstood. With these new investments, we’re closing the gap...
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Co-clinical trials of autism in mice and humans
https://braincanada.ca/funded-grants/co-clinical-trials-of-autism-in-mice-and-humansAutism is a neuro-developmental disorder characterized by social/communication deficits and repetitive behaviours. Project Overview Autism is a neuro-developmental disorder characterized by social/communication deficits and repetitive behaviours. It is very heterogeneous, with over 250 genes...
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CODEX Trial
https://braincanada.ca/funded-grants/codex-trialEach year, over 312 million patients undergo surgery. Project Overview Each year, over 312 million patients undergo surgery. Anesthesia is a drug-induced reversible, comatose state that facilitates surgery. It is widely assumed cognition returns to baseline afterwards. Surgery and anesthesia...
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Cognition and Functional Specialization in Connectome-Based Neuromorphic Networks
https://braincanada.ca/funded-grants/cognition-and-functional-specialization-in-connectome-based-neuromorphic-networksHow does the wiring of the brain confer cognitive capacity? Project Overview How does the wiring of the brain confer cognitive capacity? Technological, analytic, and theoretical advances present a unique opportunity to reconstruct brain networks in individuals. At the same time, modern artificial...
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Cognitive Outcomes and Response/Remission Efficacy of Convulsive Therapies in Treatment Resistant Depression: The CORRECT-TRD Trial
https://braincanada.ca/funded-grants/cognitive-outcomes-and-response-remission-efficacy-of-convulsive-therapies-in-treatment-resistant-depression-the-correct-trd-trialMagnetic Seizure Therapy (MST) is a novel form of treatment that uses high intensity magnetic field pulses to stimulate the brain and induce a seizure as a therapeutic intervention for patients with depression resistant to antidepressant medication, known as Treatment Resistant Depression (TRD)....