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The objective of our project is to investigate if women with carotid stenosis (CAS) have impaired cerebral blood flow (CBF) regulation in different regions of their brain. Project Overview The objective of our project is to investigate if women with carotid stenosis (CAS) have impaired cerebral...

In late 2011, a landmark discovery was made which identified that abnormalities (mutation) in a gene called C9ORF72 were responsible for the highest percentage of hereditary ALS and frontotemporal dementia cases. Project Overview In late 2011, a landmark discovery was made which identified that...

A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. Project Overview A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord. We have identified a process called “SUMOylation” that...

The human brain is made up of neural circuits that are thought to underlie all brain function. Project Overview The human brain is made up of neural circuits that are thought to underlie all brain function. These circuits are made up of contact points called synapses where individual nerve cells...

Meet the students behind the 2022 ALS Canada – Brain Canada Trainee Awards. Charlotte Manser is the recipient of a $75,000 ALS Canada – Brain Canada 2022 Trainee Award. As a PhD student at the University of Ottawa, she investigates how ALS-linked genes might contribute to the loss of normal stress...

The development of approaches to aid early detection of the transition from healthy aging to mild cognitive impairment and Alzheimer’s disease (AD) is critically important for developing targeted strategies to halt or slow disease progression. Project Overview The development of approaches to aid...

Circadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body temperature control the best known examples. Project Overview Circadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body...

A pilot project funded through a W. Garfield Weston Foundation – Brain Canada Multi-Investigator Research Initiative (MIRI) grant in 2012 proved the feasibility of repairing brain injuries in children caused by radiation treatment. Now, the team is running a phase three clinical trial to test the...

Many people with Parkinson’s disease have trouble with freezing of gait (FoG), a symptom that causes them to stop walking unexpectedly and makes them more likely to fall. Project Overview Many people with Parkinson’s disease have trouble with freezing of gait (FoG), a symptom that causes them to...

Research will shed light on how to reduce and prevent death and serious illness from heart conditions and stroke in women. Women experience distinct heart disease and stroke symptoms and risk factors that remain under-researched and misunderstood. With these new investments, we’re closing the gap...