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Each year, over 95,000 Canadians aged 65 and older are diagnosed with dementia—a number expected to rise as our population grows and ages. The diagnosis not only changes lives for those affected but also places emotional and financial strain on families, caregivers, and the health system. Voices of...

Toxic amyloid proteins are known to be a significant contributing factor in the development of Alzheimer’s disease. Project Overview Toxic amyloid proteins are known to be a significant contributing factor in the development of Alzheimer’s disease. Abnormal clusters of protein fragments build up...

Although it is now known that miRNAs act in part via post-transcriptional effects on mRNA stability and/or translation to modulate gene expression, other molecular mechanisms by which non-coding RNAs may effect changes in mRNA and protein expression remains poorly elucidated. Project...

Glioblastoma is one of the most aggressive brain cancers, with very few treatment options and a poor survival rate. Project Overview Glioblastoma is one of the most aggressive brain cancers, with very few treatment options and a poor survival rate. Current treatments, like surgery, chemotherapy,...

Background: As we age, our blood vessels (“vasculature”) can become damaged, leading to a lack of oxygen and nutrients being supplied to the brain. Project Overview Background: As we age, our blood vessels (“vasculature”) can become damaged, leading to a lack of oxygen and nutrients being supplied...

Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that build up over time and lead to large protein clumps that are toxic to the cell and lead to cell death. Project Overview Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that...

Many people living with dementia develop swallowing problems, which can make eating unsafe and stressful for families. Caregivers are often left to manage these challenges with little guidance, especially when trying to prepare foods that are both safe and culturally meaningful. Project...

Mr. Hooshmandi’s research will examine the hypothesis that reduced phosphorylation of eIF2α excessively stimulates general translation in Fmr1 KO mice during brain development, contributing to the pathophysiology of Fragile X syndrome (FXS) and potentially of other forms of autism. Project...

A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in muscle weakness and paralysis. Project Overview A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in...

za Many women experience depression during pregnancy, and are often faced with challenging decisions surrounding antidepressant use during this critical time for their developing child. Project Overview Many women experience depression during pregnancy, and are often faced with challenging...