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Mr. Hooshmandi’s research will examine the hypothesis that reduced phosphorylation of eIF2α excessively stimulates general translation in Fmr1 KO mice during brain development, contributing to the pathophysiology of Fragile X syndrome (FXS) and potentially of other forms of autism. Project...

A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in muscle weakness and paralysis. Project Overview A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in...

za Many women experience depression during pregnancy, and are often faced with challenging decisions surrounding antidepressant use during this critical time for their developing child. Project Overview Many women experience depression during pregnancy, and are often faced with challenging...

Need for project: Gliomas are among the most malignant tumors, with very poor survival rates. Project Overview Need for project: Gliomas are among the most malignant tumors, with very poor survival rates. Early diagnosis is highly desirable since it can facilitate more effective treatments of small...

Depression is one of the most common mental health challenges faced by young people, yet choosing the right treatment remains a process of trial and error. Project Overview Depression is one of the most common mental health challenges faced by young people, yet choosing the right treatment remains...

Fetal Alcohol Syndrome (FAS) is the result of in utero alcohol exposure and is characterized by central nervous system developmental impairments which causes lifelong physical and cognitive disabilities. Project Overview Fetal Alcohol Syndrome (FAS) is the result of in utero alcohol exposure and is...

Recognizing that the 9 months before birth and the early years of a child’s life are the most critical period in the shaping of the structures and functions of the brain, and the importance of high quality, culturally appropriate early childhood programming for Indigenous children and families prior...

The portable MRI scanner that Dr. Kolind and team work with to monitor multiple sclerosis progression can be controlled using a smartphone. I’m Alison, Brain Canada’s Evaluation and Special Projects Lead. My role involves evaluating programs to inform decision-making and developing concept papers...

Canadian researchers are testing an innovative app-based therapy for postpartum depression and anxiety, and measuring whether improvements in a mother’s mental health result in changes to her child’s developing brain. Brain Canada – Bell Let’s Talk clinical trial will determine if an app-based...

A G4C2 repeat expansion in C9orf72 (chromosome 9 open reading frame 72), a gene of unclear function, is the most frequent genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (C9-ALS/FTD). Project Overview A G4C2 repeat expansion in C9orf72 (chromosome 9 open reading...