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Discovery of transcriptomic biomarkers and epigenetic therapeutic targets for c9ALS and sALS
https://braincanada.ca/funded-grants/discovery-of-transcriptomic-biomarkers-and-epigenetic-therapeutic-targets-for-c9als-and-salsDr. Belzil began her research career as a PhD student at the Université de Montréal under the guidance of world renowned geneticist and Director of the Montreal Neurological Institute and Hospital, Dr. Guy Rouleau. Project Overview Dr. Belzil began her research career as a PhD student at the...
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Disrupted SUMOylation facilitates rogue TDP-43 in ALS
https://braincanada.ca/funded-grants/disrupted-sumoylation-facilitates-rogue-tdp-43-in-alsProteins are large molecules that play many essential roles in the body. Project Overview Proteins are large molecules that play many essential roles in the body. They do most of the work inside cells and are necessary for the structure, function and regulation of all tissues and organs. TDP-43 is...
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Disrupting VCP/p97-GluA1 as a novel therapeutic intervention to restore synaptic plasticity in Alzheimer’s disease: A cryo-electron microscopy (cryo-EM) based approach
https://braincanada.ca/funded-grants/disrupting-vcp-p97-glua1-as-a-novel-therapeutic-intervention-to-restore-synaptic-plasticity-in-alzheimer-s-disease-a-cryo-electron-microscopy-cryo-em-based-approachMany proteins in our brain are responsible for memory and learning. Project Overview Many proteins in our brain are responsible for memory and learning. These proteins frequently come together to form larger complexes. This study will explore the molecular structure of these complexes to find areas...
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Dissecting acetylcholine/glutamate co-transmission in the striatum: importance of individual neurotransmitter in addiction and movement disorders
https://braincanada.ca/funded-grants/dissecting-acetylcholine-glutamate-co-transmission-in-the-striatum-importance-of-individual-neurotransmitter-in-addiction-and-movement-disordersParkinson’s disease and addiction have tremendous human and economical costs for our society. Project Overview Parkinson’s disease and addiction have tremendous human and economical costs for our society. The secret to understand these pathologies lies in unravelling the functioning of a specific...
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Dissecting brain-wide functional circuits underlying social decision making by developing a naturalistic virtual reality platform of juvenile zebrafish
https://braincanada.ca/funded-grants/dissecting-brain-wide-functional-circuits-underlying-social-decision-making-by-developing-a-naturalistic-virtual-reality-platform-of-juvenile-zebrafishUnderstanding how the brain works when we make decisions during social interactions has been difficult for neuroscientists. Project Overview Understanding how the brain works when we make decisions during social interactions has been difficult for neuroscientists. This is because our brains process...
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Dissecting Inhibitory Circuit Control of Neurovascular Coupling
https://braincanada.ca/funded-grants/dissecting-inhibitory-circuit-control-of-neurovascular-couplingThe brain is one of the most energy-demanding organs in the body, yet it has no energy reserves. To function properly, it relies on a finely tuned process that increases local blood flow whenever neurons become active: a process known as neurovascular coupling (NVC). This link between brain activity...
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Dissecting PRC2 dysfunction in IDH-mutant oligodendroglioma
https://braincanada.ca/funded-grants/dissecting-prc2-dysfunction-in-idh-mutant-oligodendrogliomaA type of brain tumour called IDH-mutant glioma is the most common brain tumour in young adults aged 20 to 40. While patients can survive for over a decade, these tumours are incurable, and require repeated surgeries and aggressive treatments. These tumours come in two forms: astrocytomas and...
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Dissecting the impact of biological sex and hormones on circadian microglial rhythms in chronic pain
https://braincanada.ca/funded-grants/dissecting-the-impact-of-biological-sex-and-hormones-on-circadian-microglial-rhythms-in-chronic-painPain doesn’t feel the same at every hour of the day. Many people notice their pain is worse at night or first thing in the morning, but we don’t yet understand why. Project Overview Pain doesn’t feel the same at every hour of the day. Many people notice their pain is worse at night or first thing...
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Dissecting the shared origins of schizophrenia and chronic cannabis use: A genomic investigation
https://braincanada.ca/funded-grants/dissecting-the-shared-origins-of-schizophrenia-and-chronic-cannabis-use-a-genomic-investigationRegular cannabis use is indisputably linked to schizophrenia. Project Overview Regular cannabis use is indisputably linked to schizophrenia. However, the causal nature and direction of this link is contentious and the biological mechanisms underpinning their relationship are poorly understood....
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Distinct neuro-immune interactions drive sex differences in chronic pain
https://braincanada.ca/funded-grants/distinct-neuro-immune-interactions-drive-sex-differences-in-chronic-painOne of the most important advances in our understanding of chronic pain over the last decade or so is the realization that neurons are not the only cells in the central nervous system participating in the processing of pain signals. Project Overview One of the most important advances in our...