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Elatus: Chronically Implantable Unit-Scale Microelectrode Array Neuromodulation Technology
https://braincanada.ca/funded-grants/elatus-chronically-implantable-unit-scale-microelectrode-array-neuromodulation-technologyChallenge: Current DRE standard of care is either DBS (Medtronic, Boston Scientific), Vagus Nerve Stimulation (VNS – Livanova) or Responsive Nerve Stimulation (RNS – NeuroPace). Project Overview Challenge: Current DRE standard of care is either DBS (Medtronic, Boston Scientific), Vagus Nerve...
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Electrically guided transcranial stimulation of cells chemogenically primed for excitability a novel, non-invasive and cell type-specific approach
https://braincanada.ca/funded-grants/electrically-guided-transcranial-stimulation-of-cells-chemogenically-primed-for-excitability-a-novel-non-invasive-and-cell-type-specific-approachDr Bambico proposes to test a new and potentially groundbreaking experimental technique called EC stimulation, which will enable researchers to influence the activity of different kinds of neurons in any part of the brain without the need of major brain invasive surgery or complex genetic...
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Electrophysiological measures of proteinopathy in asymptomatic older adults
https://braincanada.ca/funded-grants/electrophysiological-measures-of-proteinopathy-in-asymptomatic-older-adultsOur project proposes the development and first-step validation of a new, noninvasive mapping procedure of proteinopathy in asymptomatic older adults. Project Overview Our project proposes the development and first-step validation of a new, noninvasive mapping procedure of proteinopathy in...
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Eleven Canadian trainees receive grants to advance their careers in neuroscience
https://braincanada.ca/about/news-updates/eleven-canadian-trainees-receive-grants-to-advance-their-careers-in-neuroscienceFrom top left to bottom right: Allison A. Dilliott, Courtney Bannerman, Jude Frie, Logan Froese, Taylor Snowden, Flavia Venetucci, Samantha Baglot, Marie-Kim St-Pierre, Leah Mercier, Sara de la Salle, Laura Best The Brain Canada Rising Stars Trainee Awards aim to recognize the excellent research...
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Elucidating the basis for ubiquitination of misfolded ALS proteins by E3 ligase Enzymes
https://braincanada.ca/funded-grants/elucidating-the-basis-for-ubiquitination-of-misfolded-als-proteins-by-e3-ligase-enzymesA pathologic feature in both sporadic and familial ALS patients is the presence of large neuronal inclusions enriched with misfolded proteins, including SOD1, TDP43 and FUS that are frequently modified with the small protein ubiquitin (Ub) Project Overview A pathologic feature in both sporadic and...
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Elucidating the microvascular origin and behavioral correlates of functional connectivity during aging
https://braincanada.ca/funded-grants/elucidating-the-microvascular-origin-and-behavioral-correlates-of-functional-connectivity-during-agingThe emerging consensus that the brain functions as a single, complex system has led to the popularity of a network approach to studying brain function. Functional connectivity, a measure of the coordinated activity between brain regions, has been observed in neuroimaging studies to change during...
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Elucidating the neurobiological impact of neonatal polydrug exposure
https://braincanada.ca/funded-grants/elucidating-the-neurobiological-impact-of-neonatal-polydrug-exposureSubstance use during pregnancy can have negative effects on infants, including congenital disabilities, delayed neurodevelopment, and long-term learning difficulties. Project Overview Substance use during pregnancy can have negative effects on infants, including congenital disabilities, delayed...
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Elucidating the Role of DNA Repair Mechanisms in Neurodevelopmental Disorders
https://braincanada.ca/funded-grants/elucidating-the-role-of-dna-repair-mechanisms-in-neurodevelopmental-disordersThis research aims to unravel the mysteries of Rett syndrome (RTT), a severe neurodevelopmental condition primarily affecting girls, characterized by mental and physical impairments. Project Overview This research aims to unravel the mysteries of Rett syndrome (RTT), a severe neurodevelopmental...
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Elucidating the role of stress granules dynamics in the pathogenesis of ALS
https://braincanada.ca/funded-grants/elucidating-the-role-of-stress-granules-dynamics-in-the-pathogenesis-of-alsThe lifetime risk of developing amyotrophic lateral sclerosis (ALS) is approximately 1 in 350 for men and 1 in 440 for women, making it the most common adult-onset motor neuron disease. Project Overview The lifetime risk of developing amyotrophic lateral sclerosis (ALS) is approximately 1 in 350...
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EMPOW-HER: Exploring methods to improve participation of women in clinical trials to help enhance stroke recovery research
https://braincanada.ca/funded-grants/empow-her-exploring-methods-to-improve-participation-of-women-in-clinical-trials-to-help-enhance-stroke-recovery-researchIn general, women take part in research less than men. Project Overview In general, women take part in research less than men. We found women take part in our research less than men too. We are a team of rehabilitation researchers located across Canada that test new treatments like drugs,...