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Amyotrophic lateral sclerosis (ALS) is a debilitating and terminal disease. Project Overview Amyotrophic lateral sclerosis (ALS) is a debilitating and terminal disease. A common hallmark of its familial and sporadic forms is the accumulation of insoluble protein aggregates in the cytoplasm of motor...

People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. Project Overview People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation. These...

Multiple sclerosis (MS) is the most common cause of non-traumatic neurological disability, affecting 1 in 400 Canadian adults. Project Overview Multiple sclerosis (MS) is the most common cause of non-traumatic neurological disability, affecting 1 in 400 Canadian adults. It occurs when the immune...

The primary motor cortex in the brain is responsible for voluntary movement. It has also been proposed to be one of the sites for motor memory formation and storage. Project Overview The primary motor cortex in the brain is responsible for voluntary movement. It has also been proposed to be one of...

More than 70 youth leaders, advocates, clinicians, researchers, policymakers, and stakeholders came together in Toronto on November 15 for an open exchange on youth mental health, hosted by Brain Canada, with support from RBC. More than 70 youth leaders, advocates, clinicians, researchers,...

Current biomarkers of ALS used by clinicians to help care for ALS patients have many drawbacks that may include cost, accessibility, and invasiveness of procedures. Project Overview Current biomarkers of ALS used by clinicians to help care for ALS patients have many drawbacks that may include cost,...

Cocaine is a highly addictive stimulant drug. Approximately 10% of Canadians aged 20-24 report current cocaine use. Project Overview Cocaine is a highly addictive stimulant drug. Approximately 10% of Canadians aged 20-24 report current cocaine use. Demand for the drug is growing and rates of...

The existing treatment regimens for children with ependymomas are generally not successful and if successful survivors are left with considerable disabilities including severely diminished IQ, focal neurological and language deficits, and endocrine deficiencies. Project Overview The existing...

As part of our mission to fund bold brain research, Brain Canada has, together with its donors and partners, supported dozens of large-scale research projects and platforms to develop and apply cutting-edge AI approaches to advance our understanding of the brain and identify solutions for brain...

Mutations in the metabolic enzymes are commonly observed in brain cancers. Project Overview Mutations in the metabolic enzymes are commonly observed in brain cancers. Although the precise molecular underpinning for this remains elusive, it has been shown that brain cancer-associated mutations in...