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Mechanisms of glutamatergic neuronal dysfunction in genetic models of ALS
https://braincanada.ca/funded-grants/mechanisms-of-glutamatergic-neuronal-dysfunction-in-genetic-models-of-alsThis project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction. Project Overview This project will focus on comprehensively studying impaired transmission of signals (from the...
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Mechanisms of in vitro synaptic transmission of mis-folded human SOD1
https://braincanada.ca/funded-grants/mechanisms-of-in-vitro-synaptic-transmission-of-mis-folded-human-sod1The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to...
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Mechanisms of response and resistance to Olaparib and Durvalumab in treatment of glioblastomas and IDH-mutated astrocytomas
https://braincanada.ca/funded-grants/mechanisms-of-response-and-resistance-to-olaparib-and-durvalumab-in-treatment-of-glioblastomas-and-idh-mutated-astrocytomasGlioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. Project Overview Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. These tumors have genetic changes that affect their ability to...
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Mechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis
https://braincanada.ca/funded-grants/mechanisms-of-synaptic-dysfunction-in-amyotrophic-lateral-sclerosisThis project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Project Overview This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on...
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Mechanisms underlying treatment-induced language recovery post-stroke
https://braincanada.ca/funded-grants/mechanisms-underlying-treatment-induced-language-recovery-post-strokeIn Canada, one individual suffers a stroke every seven minutes. Project Overview In Canada, one individual suffers a stroke every seven minutes. Of those who survive, roughly 30% will have aphasia, a difficulty speaking with- or understanding others. Aphasia can have a significant negative impact...
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Mechanistic Studies of Metabolite-Signaling Defects Causing Seizures
https://braincanada.ca/funded-grants/mechanistic-studies-of-metabolite-signaling-defects-causing-seizuresOur research program is centered on investigating the important contributions of metabolism to brain health. Project Overview Our research program is centered on investigating the important contributions of metabolism to brain health. It is generally well-accepted that proper nutrition is a major...
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Meet nine Canadian researchers moving ALS research forward with the help of the ALS Canada-Brain Canada Discovery Grant Program
https://braincanada.ca/about/news-updates/meet-nine-canadian-researchers-moving-als-research-forward-with-the-help-of-the-als-canada-brain-canada-discovery-grant-programIn March 2023, the ALS Society of Canada and Brain Canada announced the latest round of Discovery Grant recipients from their 2022 research grant competition. With support from SLA Québec and the Dr. Jean-Pierre Canuel Fund, nine Canadian researchers and their teams received a total of $1,475,000 in...
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Meet the blood pressure-pioneer of spinal cord injury.
https://braincanada.ca/about/news-updates/meet-the-blood-pressure-pioneer-of-spinal-cord-injury -
Meet the next generation of Future Leaders
https://braincanada.ca/about/news-updates/meet-the-next-generation-of-future-leaders -
Mental Health on Playing with Marbles
https://braincanada.ca/about/news-updates/mental-health-on-playing-with-marblesPHOTO: Love the brain you’re with, an e-valentine to our brains, drawn by illustrator Paterson Hodgson. Brain Canada’s podcast is back and it is exploring youth mental health A Brain Canada—Vocal Fry production, Playing with Marbles returns with Katie Jensen as host. This season is produced with...