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Investigating the role of outer radial glia in autism using human pluripotent stem cells-derived 2D neural cultures and 3D brain organoids
https://braincanada.ca/funded-grants/investigating-the-role-of-outer-radial-glia-in-autism-using-human-pluripotent-stem-cells-derived-2d-neural-cultures-and-3d-brain-organoidsThe extraordinary size and folded shape of the human brain makes us the smartest animal on earth Project Overview The extraordinary size and folded shape of the human brain makes us the smartest animal on earth. However, it also means many diseases that harm the human brain disrupt cells and...
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Investigating the role of TDP-43 in DNA Replication: Implications for ALS Pathogenesis
https://braincanada.ca/funded-grants/investigating-the-role-of-tdp-43-in-dna-replication-implications-for-als-pathogenesisCells are constantly under stress due to several environmental and internal factors. Project Overview Cells are constantly under stress due to several environmental and internal factors. Accumulating stress over a period as seen in aging and neurodegenerative diseases like Amyotrophic Lateral...
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Investigating the templated propagation and impact of pathogenic FUS in hiPSCs-derived cerebral organoids
https://braincanada.ca/funded-grants/investigating-the-templated-propagation-and-impact-of-pathogenic-fus-in-hipscs-derived-cerebral-organoidsAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle weakness and ultimately paralysis. Project Overview Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle...
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Investigating the Templated Propagation of the ALS-related Protein FUS in iPSC-derived Cerebral Organoids
https://braincanada.ca/funded-grants/investigating-the-templated-propagation-of-the-als-related-protein-fus-in-ipsc-derived-cerebral-organoidsAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and paralysis, partly due to the buildup of protein aggregates in nerve cells. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and...
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Investigating therapeutic approaches for SPTLC1 ALS variants using zebrafish models
https://braincanada.ca/funded-grants/investigating-therapeutic-approaches-for-sptlc1-als-variants-using-zebrafish-modelsWhile most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children. Project Overview While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1...
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Investigating Trans-acting Genetic Modifier Variants’ Association with Loss of Interruption (LOI) Variants and Impacts on Age of Onset in Relation to Canonical Alleles.
https://braincanada.ca/funded-grants/investigating-trans-acting-genetic-modifier-variants-association-with-loss-of-interruption-loi-variants-and-impacts-on-age-of-onset-in-relation-to-canonical-allelesHuntington’s disease (HD) age of onset is primarily determined by the CAG repeat length in the huntingtin gene (HTT); however, CAG repeat length does not fully explain the variability in age of onset observed between HD affected individuals. Approximately a dozen HD genetic modifiers have been...
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Investigation of Cerebrovascular Disease across Sexes and Neurodegenerative Disorders through Post-mortem Imaging and Histology
https://braincanada.ca/funded-grants/investigation-of-cerebrovascular-disease-across-sexes-and-neurodegenerative-disorders-through-post-mortem-imaging-and-histologyOver 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. Project Overview Over 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. In over...
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Investigation of DNA damage response as a genomic modifier in Rett syndrome
https://braincanada.ca/funded-grants/investigation-of-dna-damage-response-as-a-genomic-modifier-in-rett-syndromeRett syndrome is a severe neurological disorder that is caused by genetic mutations in the MECP2 gene. Project Overview Rett syndrome is a severe neurological disorder that is caused by genetic mutations in the MECP2 gene. The disorder almost exclusively affects females, presents in childhood and...
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Investigation of microbiota mediated suppression of motor neuron degeneration in genetic models of ALS
https://braincanada.ca/funded-grants/investigation-of-microbiota-mediated-suppression-of-motor-neuron-degeneration-in-genetic-models-of-alsScientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape. Project Overview Scientists have long wondered what the contribution of environment is to ALS and in...
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Investigation of neuroinflammation and microglial subtypes associated with ALS
https://braincanada.ca/funded-grants/investigation-of-neuroinflammation-and-microglial-subtypes-associated-with-alsThe common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is neuronal death. Project Overview The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD),...
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