Funded Grants

There is an urgent need for research that deepens our understanding of human brain function and uses this knowledge to accelerate therapeutic breakthroughs related to brain dysfunction.

Regardless of disease etiology, ~97% of ALS patients display TDP-43 pathology. TDP-43 is an RNA-binding protein that is involved in the cellular stress response. Following a stressor, TDP-43 translocates to the cytosol and is thought to be protective. However, with chronic stress and/or ALS-relevant mutations TDP-43 is depleted from the nucleus by translocating to the cytosol, where it ultimately aggregates.

Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumour in adults.

Glioblastoma (GBM) is the most common and deadly adult brain cancer.

Optogenetics, defined as a technique where light-sensitive genes are introduced into brain cells to control their activity with light, allows researchers to precisely control nerve cell communication thereby, transforming brain research.

Background: As we age, our blood vessels (“vasculature”) can become damaged, leading to a lack of oxygen and nutrients being supplied to the brain.

Nearly half the people affected with Alzheimer’s disease will at some point show reduced motivation to perform their daily activities or participate in activities they previously enjoyed.

Our research project will investigate the relationship between physical activity and brain vascular health in women.

Amyotrophic lateral sclerosis (ALS) is marked by dysfunction and degeneration of neuromuscular junctions (NMJ).

“La bonne intervention, au bon moment, pour le bon enfant”.