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839 results found

Specific translation of mRNAs encoding primary cilia components as a new resistance mechanism in glioblastoma

We are studying a type of brain tumour called glioblastoma (GBM), which is often fatal despite current treatments.


Grant type
Capacity building grants
Area of Research
Cancer
Competition
CRS Operating Grants
Province
Ontario
Start Date
2024

Identification of the Neural Circuitry of Persistent Depressive Symptoms in First-Episode Schizophrenia: From Biomarkers to Predictive Imaging

People with schizophrenia often suffer from depressive and negative symptoms, such as reduced emotional expression, or less motivation.


Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Rising Stars Trainee Awards
Province
Ontario
Start Date
2024

Brain-heart dynamics in treatment-resistant depression and the effects of repetitive transcranial magnetic stimulation

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation therapy, recommended by Canadian guidelines as a first-line intervention for major depression that does not respond to an adequate course of pharmacological therapy, known as treatment-resistant depression (TRD).


Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Rising Stars Trainee Awards
Province
British Columbia
Start Date
2024

Defective protein translation: a causative pathway in ALS

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with the brain and spinal cord.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Rising Stars Trainee Awards
Province
British Columbia
Start Date
2024

Multi-modal neuroimaging biomarkers of Parkinson’s disease progression

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the world.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Rising Stars Trainee Awards
Province
Québec
Start Date
2024

Unravelling Molecular Mechanisms of ALS: Characterizing the in vitro and in vivo effects of biometals on the ALS-linked proteins TDP-43, SOD1, PGRN, and MFSD8

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons, typically resulting from gene mutations that facilitate abnormal protein aggregation.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Rising Stars Trainee Awards
Province
Ontario
Start Date
2024

Role of the gut microbiome-brain axis in sexual dimorphism of ALS

Males are twice as likely to develop ALS compared to females and the disease onset is also earlier in males than females.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Rising Stars Trainee Awards
Province
Alberta
Start Date
2024

Characterizing the effects of blocking TDP-43 SUMOylation during cellular stress and recovery using live-cell imaging

A common feature in almost all ALS cases is the build up of a protein called TDP-43 in the brain and spinal cord.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Rising Stars Trainee Awards
Province
Ontario
Start Date
2024

A combined in-vivo ex-vivo approach to investigate imaging biomarkers in ALS diagnosis and aetiology

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately death.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Rising Stars Trainee Awards
Province
Québec
Start Date
2024

CODEX Trial

Each year, over 312 million patients undergo surgery.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Alzheimer's Association International Grant Program
Province
Ontario
Start Date
2024