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Almost 9% of Canadians have ADHD, however it is likely higher as more girls and women are being diagnosed.

"Antisense oligonucleotides (ASOs) are synthetic single-stranded DNA/RNA that are useful in the targeting of mRNA sequences."

A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in muscle weakness and paralysis.

Study of perisynaptic Schwann cells contribution on NMJ reinnervation efficiency in ALS

"Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment and cognitive decline."

Depression is a leading cause of disability, with a large proportion of treatment-resistant patients. Recent studies have implicated reduced brain inhibition in human depression from a specific neuron type (SST), and new pharmacology boosting this reduced inhibition led to antidepressant and pro-cognitive effects in rodents.

Regardless of disease etiology, ~97% of ALS patients display TDP-43 pathology. TDP-43 is an RNA-binding protein that is involved in the cellular stress response. Following a stressor, TDP-43 translocates to the cytosol and is thought to be protective. However, with chronic stress and/or ALS-relevant mutations TDP-43 is depleted from the nucleus by translocating to the cytosol, where it ultimately aggregates.

We discovered that approximately one fifth of people with the deadly brain tumour glioblastoma show age-related genetic changes in their blood cells called ‘clonal hematopoiesis’, or CHIP.

The MIND Platform is a groundbreaking initiative that will revolutionize brain research by allowing scientists to capture and analyze unprecedented detailed images of the brain at both large and small scales.

Neuroscience is on the brink of a digital revolution, where vast amounts of data from diverse individuals are supporting the creation of powerful predictive models of brain disorders.