Funded Grants

Although the spinal cord contains all the circuitry necessary for locomotion, due to the absence of commands from the brain, people with spinal cord injuries are unable to walk.

The main goal of my project is to further characterize the role of Wnt signalling in glioma progression.

We propose a randomized controlled trial to evaluate the efficacy of Goal Management Training (GMT) for improving these patients’ cognitive functioning as well as patient and caregiver QoL.

This study will provide more in-depth information on all individuals with malignant and benign brain tumours in Ontario and their utilization of health care services at the provincial and local level.

Developmental signaling pathways are known to play important roles in normal neural stem cell (NSC) dynamics and can significantly alter the development of gliomas, highly aggressive brain tumours that arise from NSC-like tumour-initiating cells (TIC).

The broad aim of this project is to develop and evaluate nonlinear registration techniques that account for discontinuities in data from tissue resection in order to accurately reflect the deformed brain.

A recent study by the Massague group has identified genes that mediated breast cancer metastasis to the brain by using genomic expression analysis to compare in vivo-selected brain metastasis cell lines to the corresponding parental lines.

Although it is now known that miRNAs act in part via post-transcriptional effects on mRNA stability and/or translation to modulate gene expression, other molecular mechanisms by which non-coding RNAs may effect changes in mRNA and protein expression remains poorly elucidated.

The serotonin transporter (5-HTT) is a protein that clears extracellular serotonin from the synapses and depletion of serotonin is associated with depressive symptoms.

Mr. Baimel’s work focuses upon the role of the neuropeptide, orexin, and its role in modulating the neural region which regulates reward sensations, the ventral tegmental area (VTA).