Funded Grants

TDP-43, SOD1, and FUS proteinopathies in vivo: interrogating prion-like mechanisms and drug rescue in zebrafish and ALS hiPSC-derived neuron xenotransplant models

Enzymes are mother nature’s catalysts responsible for the chemistry of metabolic pathways in living cells. In some diseases, the function of an enzyme is deficient which can lead to dysfunction or early cell death.

Multiple Sclerosis (MS) is a disease that affects the brain and spinal cord, leading to a gradual loss of nerve function. Canada—especially Saskatchewan—has the highest rates of MS in the world.

Exercise and rehabilitation can help people with neurological conditions to improve physical function even years after a diagnosis. Yet, after hospital discharge, there are few available services for people with neurological conditions.

This research explores how lightly touching another person, called interpersonal light touch (IPLT), can help people stay balanced while standing.

Canada has one of the highest rates of MS in the world, with treatment costing an estimated $2 billion per year by 2031. Even with modern treatments, persons living with MS accumulate long-term neurological disability over time.

Many people in northern and Indigenous communities in Saskatchewan face challenges in accessing mental health support due to distance, limited services, and long wait times.

Managing chronic health conditions like chronic pain and Fetal Alcohol Spectrum Disorder (FASD) can be challenging, especially when support is limited. Our team has developed a mobile app called HELP (Health Education and Learning Platform) to support people in managing their health.

Epilepsy is a severe neurological disorder that affects approximately 300,000 Canadians. Temporal lobe epilepsy is the most common form of epilepsy in adults and is characterized by seizures that cause abnormal sensations, impaired consciousness, and loss of motor control.

Anxiety disorders affect women twice as often as men; symptom profile and response to treatment are also different depending on biological sex. This sex difference in anxiety disorders – and mood disorders in general – is well documented, yet, we still have an incomplete understanding of the neurobiological mechanisms at play.