Stimulation-based Multi-Scale Inference of Brain Dynamics in Humans with Neurological Disorders
Deep brain stimulation (DBS) has been successfully used to reduce symptoms of Parkinson’s disease by delivering electrical pulses to the substructures of the basal ganglia and thalamus. Despite successful clinical outcomes of DBS, less consideration has been given to how DBS modulates information processing in the human brain. Here, we will develop techniques in computational neuroscience and record in-vivo in patients with Parkinson’s disease to discover how modulated neural activities observed in different sub-cortical regions are linked to each other in a mechanistic way. The outcomes of this project will be essential to establish a network-level understanding of DBS-modulated information processing.
Milad Lankarany , University Health Network
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