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The Toronto Dementia Research Alliance (TDRA) Dementia Clinical Research Database: A Platform in Neurodegenerative Diseases

Principal Investigator:
  • Morris Freedman, Rotman Research Institute
Team Members:
  • Stephen Strother, Rotman Research Institute
  • David Tang-Wai, University Health Network
  • Sandra Black, Sunnybrook Health Sciences Centre
  • Mario Masellis, Sunnybrook Health Sciences Centre
  • Corinne Fischer, St. Michael's Hospital
  • Alan Moody, Sunnybrook Health Sciences Centre
  • Paula Rochon, Women's College Hospital
  • Carmela Tartaglia, University Health Network
  • Nathan Herrmann, Sunnybrook Health Sciences Centre
  • Barry Greenberg, Krembil Research Institute
  • Donald Weaver, Toronto Western Research Institute, University of Toronto
  • Ron Keren, University Health Network
  • Barry Goldlist, University Health Network
  • Uri Wolf, Baycrest
  • Paul Verhoeff, Baycrest
  • Gary Naglie, Baycrest
  • A. Randy MacIntosh, Rotman Research Institute
  • William Reichman, Baycrest
  • Sanjeev Kumar, Centre for Addiction and Mental Health
  • Tarek Rajji, Centre for Addiction and Mental Health
  • Benoit Mulsant, CAMH, University of Toronto
  • Suvendrini Lena, Centre for Addiction and Mental Health
  • Sean Symons, Sunnybrook Health Sciences Centre
  • Krista Lanctot, Sunnybrook Health Sciences Centre
  • Walter Montanera, St. Michael's Hospital
  • Angie Troyer, Baycrest
  • Tom Schweizer, St. Michael's Hospital
  • Kathryn Stokes, Baycrest
  • Mary-Pat McAndrews, University Health Network
  • Prathiba Shammi, Sunnybrook Health Sciences Centre
  • Linda Mah, Rotman Research Institute, Baycrest Centre
  • Wendy Lou, University of Toronto
  • Kevin Thorpe, University of Toronto
  • Pascal Tyrrell, University of Toronto
  • Bruce Pollock, Centre for Addiction and Mental Health
  • Alex Kiss, Sunnybrook Health Sciences Centre
  • Malcolm Binns, Baycrest Health Sciences
  • Tamara Arenovich, Centre for Addiction and Mental Health
  • Susan Bronskill, ICES
  • Cheryl Grady, Baycrest
  • General Leung, St. Michael's Hospital
  • Sapna Rawal, University Health Network
  • David Mikulis, University Health Network
  • University of Toronto
  • Centre for Addiction and Mental Health
  • Baycrest
  • Sunnybrook Health Sciences Centre
  • University Health Network

Project Overview

The Toronto Dementia Research Alliance will establish a clinical research platform that will provide a consistent and efficient approach to managing research and clinical care in patients with neurodegenerative conditions. The platform will provide epidemiological data, track disease burden, fill gaps in medical evidence such as therapeutic effectiveness, performance measurement for the purpose of quality improvement, and enable evaluation of “real world” effectiveness of medical therapies in practice outside the highly controlled conditions of clinical trials. Complementary information obtained through future linkage beyond the 3-year term of this project with the provincial Institute for Clinical Evaluative Sciences (ICES) will provide additional information to manage and improve the effectiveness of the health system, and identify ineffective interventions, missed opportunities and duplication of services. This will lead to better management and evaluation of public health interventions including health promotion and risk reduction, all of which can impact on decreasing costs to the healthcare system. The platform will also have the flexibility to create and enter new standardized information in the face of advancing knowledge, thus contributing to sustainability within the context of a basic framework. This platform will provide a resource to accelerate innovation for research in neurodegenerative diseases, access to data sets for detailed cohort studies and appropriate patient selection for entry into therapeutic clinical trials.