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Stroke affects 17% of people worldwide and some estimates predict that it will soon become the most common cause of death worldwide. Project Overview Stroke affects 17% of people worldwide and some estimates predict that it will soon become the most common cause of death worldwide. Post-stroke...

Brain cancers can be exceptionally challenging to treat, and new therapies are needed. Project Overview Brain cancers can be exceptionally challenging to treat, and new therapies are needed. Cancer cells can resist treatment in part through proteins that protect cells from dying called IAPs. Dr...

Optogenetic strategies – the ability to activate normally light-insensitive neurons with light – are being used in clinical trials to restore light sensitivity to the retina of vision impaired patients. Project Overview Optogenetic strategies – the ability to activate normally light-insensitive...

Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumour in adults. Project Overview Glioblastoma Multiforme (GBM) is the most common and aggressive brain tumour in adults. Current treatment includes surgical resection, chemotherapy, and radiation. However, since GBM is...

Dementia is becoming more prevalent with the aging of the baby boomer population and is imposing a major challenge to society, both from a financial and social perspective. Project Overview Dementia is becoming more prevalent with the aging of the baby boomer population and is imposing a major...

The brain is isolated from the peripheral blood circulation by a barrier (ie the blood-brain barrier) that protects it from the entrance of harmful substances (pathogenic or inflammatory agents) and prevents excessive fluctuations in the levels of circulating molecules. Project Overview The brain...

Metabolic syndrome is a group of risk factors (obesity, hypertension, high fasting blood sugar, and high levels of triglycerides) that increase the risk of type 2 diabetes and cardiovascular diseases. Project Overview Metabolic syndrome is a group of risk factors (obesity, hypertension, high...

Periodontal disease has links with Alzheimer’s disease. Project Overview Periodontal disease has links with Alzheimer’s disease. The bacterium Porphyromonas gingivalis plays a major role in gum disease and has been associated with Alzheimer’s disease. We have identified a small protein, produced by...

A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Project Overview A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the...

Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD) are devastating diseases in which a protein called TDP-43 ends up in the wrong part of the cell, disrupting its normal role in managing RNA. Project Overview Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD)...