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Glioblastoma multiforme (GBM) the most common form of brain cancer in adults with very low survival of only 15 months with less than 5% of patients surviving more than 5 years. Surgery, chemotherapy, and radiation are the treatments currently used but recurrence is very common, often with tumors...

Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Project Overview Background Within the brain, cells communicate by sending signals that either enhance or dampen the activity of other cells. Balancing these excitatory and inhibitory...

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease with distinct genetic contributions. Project Overview Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease with distinct genetic contributions. However, even for genetically defined components of...

Alzheimer’s Disease (AD) affects many people and leads to memory loss and cognitive decline. It is linked to brain inflammation and changes in proteins like GFAP, which is usually found in support cells called astrocytes. Project Overview Alzheimer’s Disease (AD) affects many people and leads to...

Spinal cord injury leads to permanent and severe paralysis and loss of sensation. Project Overview Spinal cord injury leads to permanent and severe paralysis and loss of sensation. The principal reason for this is that nerve cells connecting the brain with the rest of the body lose the capacity to...

The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. Project Overview The immune system is responsible for protecting the body against diseases, but it can also play a role in tumor formation. By exploring the role of these cells...

Individuals with or at increased risk of Alzheimer’s disease (AD) have an altered community of microbes(microbiome) within the intestinal tract. Project Overview Individuals with or at increased risk of Alzheimer’s disease (AD) have an altered community of microbes(microbiome) within the intestinal...

Autism spectrum disorders are neurodevelopmental disorders characterized by deficits in social interaction, poor communication, and restricted, stereotyped patterns of behavior. Project Overview Autism spectrum disorders are neurodevelopmental disorders characterized by deficits in social...

Cancer can exhibit relentless growth and relapse because of the enhanced protection of its chromosome ends. Project Overview Cancer can exhibit relentless growth and relapse because of the enhanced protection of its chromosome ends. Dr. Uri Tabori is a world expert in telomeres – the protective...

Alzheimer’s disease progresses over time due to the spreading of aggregates of tau protein and amyloid protein from unaffected to affected regions of the brain. Project Overview Alzheimer’s disease progresses over time due to the spreading of aggregates of tau protein and amyloid protein from...