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Using neuroimaging to predict recovery from acute brain injury
https://braincanada.ca/funded-grants/using-neuroimaging-to-predict-recovery-from-acute-brain-injuryWhen a person suffers a severe brain injury, whether from an accident, stroke, or infection, clinicians struggle to predict if they will recover. Project Overview When a person suffers a severe brain injury, whether from an accident, stroke, or infection, clinicians struggle to predict if they will...
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Using Novel Approaches for Early Recognition of TIA, Heart Failure, and Connections with Vascular Dementia (UNEARTH CVD)
https://braincanada.ca/funded-grants/using-novel-approaches-for-early-recognition-of-tia-heart-failure-and-connections-with-vascular-dementia-unearth-cvdIn this program, we will study: 1) patients with stroke, which occurs when blood flow is stopped to a part of the brain causing weakness or loss of sensation;2) patients with heart failure which is when the heart does not pump properly or does not relax; 3) patients with dementia, which is deficit...
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Using synthetic antibody parts to construct antibody-based imaging devices – anti-EGFR molecular targeted imaging probes for diagnosing and monitoring glioblastoma
https://braincanada.ca/funded-grants/using-synthetic-antibody-parts-to-construct-antibody-based-imaging-devices-anti-egfr-molecular-targeted-imaging-probes-for-diagnosing-and-monitoring-glioblastomaTo improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy. Project Overview To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and...
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Using targeted ultrasound to get immunotherapy drugs past the blood-brain barrier
https://braincanada.ca/funded-grants/using-targeted-ultrasound-to-get-immunotherapy-drugs-past-the-blood-brain-barrierStephanie Borlase is investigating ways to improve immunotherapies to treat people whose lung cancer has spread to the brain, improving outcomes. Project Overview Stephanie Borlase is investigating ways to improve immunotherapies to treat people whose lung cancer has spread to the brain, improving...
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Using tropical fish to find treatments for brain disorders
https://braincanada.ca/about/news-updates/using-tropical-fish-to-find-treatments-for-brain-disordersThe traditional target-based drug development strategy (in vitro screening) has had poor success in developing new drugs. The vast majority of Investigational New Drugs (INDs) fail in clinical trials due to toxicity or lack of efficacy. On the other hand, mammalian models are excellent tools to...
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Using worms to investigate the disease mechanisms of ALS
https://braincanada.ca/about/news-updates/using-worms-to-investigate-the-disease-mechanisms-of-alsThe project Alex Parker and his team are focused on developing and using simple models to study brain diseases, specifically ALS. The model system they use is the Caenorhabditis elegans (C. elegans) worm. This small, transparent worm has just 300 neurons, but is a powerful genetic system used by...
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Utilizing next generation intersectional approaches to define the roles of POMC neuron subpopulations
https://braincanada.ca/funded-grants/utilizing-next-generation-intersectional-approaches-to-define-the-roles-of-pomc-neuron-subpopulationsThe central nervous system controls numerous processes, including appetite and body weight regulation. Project Overview The central nervous system controls numerous processes, including appetite and body weight regulation. Given the alarming rise in global obesity, understanding how the CNS...
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Validation of cognitive rehabilitation program adapted to the needs of adults with brain cancer and adult survivors of childhood brain cancer.
https://braincanada.ca/funded-grants/validation-of-cognitive-rehabilitation-program-adapted-to-the-needs-of-adults-with-brain-cancer-and-adult-survivors-of-childhood-brain-cancerWe propose a randomized controlled trial to evaluate the efficacy of Goal Management Training (GMT) for improving these patients’ cognitive functioning as well as patient and caregiver QoL. Project Overview We propose a randomized controlled trial to evaluate the efficacy of Goal Management...
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Validation of Connexins and Pannexins as a target for Alzheimer’s Disease
https://braincanada.ca/funded-grants/validation-of-connexins-and-pannexins-as-a-target-for-alzheimer-s-diseaseAlzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. Project Overview Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As...
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Validation of ocular measures as potential biomarkers for early detection of brain amyloid and neurodegeneration
https://braincanada.ca/funded-grants/validation-of-ocular-measures-as-potential-biomarkers-for-early-detection-of-brain-amyloid-and-neurodegeneration500,000 Canadians have dementia, a number that will double within a generation due to the ongoing aging demographics of the population, with annual costs estimated to increase from $15B currently to over $150B by the year 2050. Project Overview 500,000 Canadians have dementia, a number that will...
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