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Validation of small molecules preventing TDP-43 aggregation as a therapeutic for Amyotrophic Lateral Sclerosis
https://braincanada.ca/funded-grants/validation-of-small-molecules-preventing-tdp-43-aggregation-as-a-therapeutic-for-amyotrophic-lateral-sclerosisTDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. Project Overview TDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. It is usually found in the nucleus, but in people with ALS, it becomes trapped...
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Vascular innervation and blood-brain barrier dysfunction in Huntington’s disease using human iPSC-derived vascularized brain organoids.
https://braincanada.ca/funded-grants/vascular-innervation-and-blood-brain-barrier-dysfunction-in-huntington-s-disease-using-human-ipsc-derived-vascularized-brain-organoids“Vascular pathology, such as loss of neurovascular coupling and disruption of the blood-brain barrier (BBB), has been documented in Huntington’s disease (HD). Project Overview “Vascular pathology, such as loss of neurovascular coupling and disruption of the blood-brain barrier (BBB), has been...
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Vascular Interface with the Brain and Neurocognition via the Eyes (VIBE): Retinal Photography in Youth with Psychiatric Disorders
https://braincanada.ca/funded-grants/vascular-interface-with-the-brain-and-neurocognition-via-the-eyes-vibe-retinal-photography-in-youth-with-psychiatric-disordersThe goal of this study is to advance knowledge regarding the association of vascular risk factors and blood vessels with brain structure and function in youth with severe mental illness. Project Overview The goal of this study is to advance knowledge regarding the association of vascular risk...
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Verifying aerobic training protocols to benefit both heart and brain in subacute stroke
https://braincanada.ca/funded-grants/verifying-aerobic-training-protocols-to-benefit-both-heart-and-brain-in-subacute-strokeBecause of low fitness and heart problems, people with stroke are at very high risk of a second stroke or heart attack within 10 years. Project Overview Because of low fitness and heart problems, people with stroke are at very high risk of a second stroke or heart attack within 10 years. Exercise...
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Volunteer Linda Auger Morissette’s annual fundraising walk in Saint-Basile-de-Portneuf raises more than $10,000 for ALS research
https://braincanada.ca/about/news-updates/volunteer-linda-auger-morissette-s-annual-fundraising-walk-in-saint-basile-de-portneuf-raises-more-than-10-000-for-als-researchMonica Berger, Brain Canada's National Director of Philanthropy (left), along with Linda Auger Morissette (right), the leader of The Perseids of Hope annual walk to support ALS research. In 2017, Linda Auger Morissette’s brother, Pierre, received an amyotrophic lateral sclerosis (ALS) diagnosis at...
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Walking into a Virtual World: A Pilot Randomized Trial using Virtual Reality and Omnidirectional Treadmill Training for People with Chronic Stroke
https://braincanada.ca/funded-grants/walking-into-a-virtual-world-a-pilot-randomized-trial-using-virtual-reality-and-omnidirectional-treadmill-training-for-people-with-chronic-strokeCognitive function (thinking, memory, and concentration), balance, and walking problems affect the lives of many stroke survivors. Project Overview Cognitive function (thinking, memory, and concentration), balance, and walking problems affect the lives of many stroke survivors. Virtual reality (VR)...
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What a new mouse model can teach us about weight loss, metabolism, and ALS
https://braincanada.ca/about/news-updates/what-a-new-mouse-model-can-teach-us-about-weight-loss-metabolism-and-als“We would like to bring hope to ALS patients. Our final goal is to find something that could really help alleviate the symptoms in ALS patients. That’s a long-term goal, but this study might be a first step to a novel therapeutic approach.” Dr. Hoon-Ki Sung Two of the prominent hallmarks of ALS are...
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What a new mouse model can teach us about weight loss, metabolism, and ALS
https://braincanada.ca/about/news-updates/what-a-new-mouse-model-can-teach-us-about-weight-loss-metabolism-and-als-2022Dr. Hoon-Ki Sung (left) and Dr. Jeehye Park “We would like to bring hope to ALS patients. Our final goal is to find something that could really help alleviate the symptoms in ALS patients. That’s a long-term goal, but this study might be a first step to a novel therapeutic approach.” – Dr. Hoon-Ki...
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What are memories and how can they help us treat brain diseases?
https://braincanada.ca/about/news-updates/what-are-memories-and-how-can-they-help-us-treat-brain-diseasesDr. Mark Cembrowski, a 2019 Azrieli Future Leader in Canadian Brain Research and investigator at the Djavad Mowafaghian Centre for Brain Health, is seeking an answer to one of the most pressing questions in neuroscience. What is memory? Through Dr. Cembrowski’s research, he is exploring how we form...
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What is the microglial scar?
https://braincanada.ca/about/news-updates/what-is-the-microglial-scarDr. Steve Lacroix, recipient of the 2020 Turnbull-Tator Award in Spinal Cord Injury and Concussion Research.
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