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Discovering how brain cancer evolution affects responses to treatment
https://braincanada.ca/funded-grants/discovering-how-brain-cancer-evolution-affects-responses-to-treatmentA type of brain cancers called “diffuse gliomas” currently lacks effective treatments. Project Overview A type of brain cancers called “diffuse gliomas” currently lacks effective treatments. One obstacle to developing new therapies is the disease variability between patients. Several categories of...
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Discovery Grant gives lab capacity to deepen its focus on ALS
https://braincanada.ca/about/news-updates/discovery-grant-gives-lab-capacity-to-deepen-its-focus-on-als“This grant was so validating. It showed us that our questions, no matter how ‘out there’, were heading in the right direction.” – Dr. Maxime Rousseaux TDP-43 is a protein that lives in the nucleus of our cells. But in at least 97 per cent of ALS patients, TDP-43 somehow finds its way out of the...
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Discovery of Therapeutic Targets for FUS- and TDP43-Dependent Forms of ALS
https://braincanada.ca/funded-grants/discovery-of-therapeutic-targets-for-fus-and-tdp43-dependent-forms-of-alsThe four most commonly studied ALS proteins are SOD1, TDP-43, FUS and C9ORF72 Project Overview The four most commonly studied ALS proteins are SOD1, TDP-43, FUS and C9ORF72. Of these, TDP-43 and FUS have the most in common. Not only do they share similar functions inside cells, but in motor neurons...
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Discovery of transcriptomic biomarkers and epigenetic therapeutic targets for c9ALS and sALS
https://braincanada.ca/funded-grants/discovery-of-transcriptomic-biomarkers-and-epigenetic-therapeutic-targets-for-c9als-and-salsDr. Belzil began her research career as a PhD student at the Université de Montréal under the guidance of world renowned geneticist and Director of the Montreal Neurological Institute and Hospital, Dr. Guy Rouleau. Project Overview Dr. Belzil began her research career as a PhD student at the...
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Disrupted SUMOylation facilitates rogue TDP-43 in ALS
https://braincanada.ca/funded-grants/disrupted-sumoylation-facilitates-rogue-tdp-43-in-alsProteins are large molecules that play many essential roles in the body. Project Overview Proteins are large molecules that play many essential roles in the body. They do most of the work inside cells and are necessary for the structure, function and regulation of all tissues and organs. TDP-43 is...
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Disrupting VCP/p97-GluA1 as a novel therapeutic intervention to restore synaptic plasticity in Alzheimer’s disease: A cryo-electron microscopy (cryo-EM) based approach
https://braincanada.ca/funded-grants/disrupting-vcp-p97-glua1-as-a-novel-therapeutic-intervention-to-restore-synaptic-plasticity-in-alzheimer-s-disease-a-cryo-electron-microscopy-cryo-em-based-approachMany proteins in our brain are responsible for memory and learning. Project Overview Many proteins in our brain are responsible for memory and learning. These proteins frequently come together to form larger complexes. This study will explore the molecular structure of these complexes to find areas...
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Dissecting acetylcholine/glutamate co-transmission in the striatum: importance of individual neurotransmitter in addiction and movement disorders
https://braincanada.ca/funded-grants/dissecting-acetylcholine-glutamate-co-transmission-in-the-striatum-importance-of-individual-neurotransmitter-in-addiction-and-movement-disordersParkinson’s disease and addiction have tremendous human and economical costs for our society. Project Overview Parkinson’s disease and addiction have tremendous human and economical costs for our society. The secret to understand these pathologies lies in unravelling the functioning of a specific...
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Dissecting brain-wide functional circuits underlying social decision making by developing a naturalistic virtual reality platform of juvenile zebrafish
https://braincanada.ca/funded-grants/dissecting-brain-wide-functional-circuits-underlying-social-decision-making-by-developing-a-naturalistic-virtual-reality-platform-of-juvenile-zebrafishUnderstanding how the brain works when we make decisions during social interactions has been difficult for neuroscientists. Project Overview Understanding how the brain works when we make decisions during social interactions has been difficult for neuroscientists. This is because our brains process...
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Dissecting Inhibitory Circuit Control of Neurovascular Coupling
https://braincanada.ca/funded-grants/dissecting-inhibitory-circuit-control-of-neurovascular-couplingThe brain is one of the most energy-demanding organs in the body, yet it has no energy reserves. To function properly, it relies on a finely tuned process that increases local blood flow whenever neurons become active: a process known as neurovascular coupling (NVC). This link between brain activity...
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Dissecting the impact of biological sex and hormones on circadian microglial rhythms in chronic pain
https://braincanada.ca/funded-grants/dissecting-the-impact-of-biological-sex-and-hormones-on-circadian-microglial-rhythms-in-chronic-painPain doesn’t feel the same at every hour of the day. Many people notice their pain is worse at night or first thing in the morning, but we don’t yet understand why. Project Overview Pain doesn’t feel the same at every hour of the day. Many people notice their pain is worse at night or first thing...
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