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Dr. Tamara Vanderwal of Vernon receives $100,000 research grant from Brain Canada
https://braincanada.ca/about/news-updates/dr-tamara-vanderwal-of-vernon-receives-100-000-research-grant-from-brain-canadaVernon’s Dr. Tamara Vanderwal is among 20 researchers to each receive a $100,000 grant to fuel their work. Read the full story here.
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Driving Open Science Innovation
https://braincanada.ca/about/news-updates/driving-open-science-innovationPHOTO: From left: Dr. Pia Wintermark, The Montreal Children’s Hospital and The Research Institute of the McGill University Health Centre (Child Health and Human Development Program), Dr. Viviane Poupon, Brain Canada President & CEO, and Dr. Nadia Gosselin, CIUSSS du Nord de l’Île-de-Montréal and...
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Driving Research
https://braincanada.ca/about/news-updates/driving-researchEach year, over 95,000 Canadians aged 65 and older are diagnosed with dementia—a number expected to rise as our population grows and ages. The diagnosis not only changes lives for those affected but also places emotional and financial strain on families, caregivers, and the health system. Voices of...
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Drug Delivery across the Human Blood-Brain Barrier
https://braincanada.ca/funded-grants/drug-delivery-across-the-human-blood-brain-barrierToxic amyloid proteins are known to be a significant contributing factor in the development of Alzheimer’s disease. Project Overview Toxic amyloid proteins are known to be a significant contributing factor in the development of Alzheimer’s disease. Abnormal clusters of protein fragments build up...
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Drug repurposing in medulloblastoma using integrated functional genomic, epigenomic, and transcriptomic approaches
https://braincanada.ca/funded-grants/drug-repurposing-in-medulloblastoma-using-integrated-functional-genomic-epigenomic-and-transcriptomic-approachesAlthough it is now known that miRNAs act in part via post-transcriptional effects on mRNA stability and/or translation to modulate gene expression, other molecular mechanisms by which non-coding RNAs may effect changes in mRNA and protein expression remains poorly elucidated. Project...
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Dual-Actuated Acoustic Microbubble Microrobots for Targeted and Precision Brain Tumour Treatment
https://braincanada.ca/funded-grants/dual-actuated-acoustic-microbubble-microrobots-for-targeted-and-precision-brain-tumour-treatmentGlioblastoma is one of the most aggressive brain cancers, with very few treatment options and a poor survival rate. Project Overview Glioblastoma is one of the most aggressive brain cancers, with very few treatment options and a poor survival rate. Current treatments, like surgery, chemotherapy,...
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Dynamic interplay of vascular injury and inflammation on AD progression
https://braincanada.ca/funded-grants/dynamic-interplay-of-vascular-injury-and-inflammation-on-ad-progressionBackground: As we age, our blood vessels (“vasculature”) can become damaged, leading to a lack of oxygen and nutrients being supplied to the brain. Project Overview Background: As we age, our blood vessels (“vasculature”) can become damaged, leading to a lack of oxygen and nutrients being supplied...
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Dynamic palmitoylation regulates TDP-43 nucleocytoplasmic transport in ALS
https://braincanada.ca/funded-grants/dynamic-palmitoylation-regulates-tdp-43-nucleocytoplasmic-transport-in-alsCommon features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that build up over time and lead to large protein clumps that are toxic to the cell and lead to cell death. Project Overview Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that...
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Dysregulation of integrated stress response (ISR) pathway in Fragile X syndrome and autism
https://braincanada.ca/funded-grants/dysregulation-of-integrated-stress-response-isr-pathway-in-fragile-x-syndrome-and-autismMr. Hooshmandi’s research will examine the hypothesis that reduced phosphorylation of eIF2α excessively stimulates general translation in Fmr1 KO mice during brain development, contributing to the pathophysiology of Fragile X syndrome (FXS) and potentially of other forms of autism. Project...
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Démêler l’altération du système endocannabinoïde dans la SLA : une nouvelle méthode thérapeutique axée sur la jonction neuromusculaire
https://braincanada.ca/funded-grants/démêler-l-altération-du-système-endocannabinoïde-dans-la-sla-une-nouvelle-méthode-thérapeutique-axée-sur-la-jonction-neuromusculaireA hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in muscle weakness and paralysis. Project Overview A hallmark and the earliest event taking place in ALS is the denervation of neuromuscular junctions (NMJs), which results in...