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Future Leaders in Canadian Brain Research – Momentum Grants
https://braincanada.ca/about/news-updates/future-leaders-in-canadian-brain-research-momentum-grants-2The Momentum Grants program allows previous Future Leaders in Canadian Brain Research grant recipients to capitalize on the momentum generated through their seed funding Brain Canada is pleased to announce a new program to leverage the strengths of the Future Leaders in Canadian Brain Research...
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Gangliosides in Huntington’s disease: from bench to clinics and back
https://braincanada.ca/funded-grants/gangliosides-in-huntington-s-disease-from-bench-to-clinics-and-backHuntington disease (HD) is an inherited disorder that causes progressive malfunctioning and death of parts of the brain that control movement, reasoning and emotions. Project Overview Huntington disease (HD) is an inherited disorder that causes progressive malfunctioning and death of parts of the...
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Garden of Resilience: Stories of Disruption and Adaptation during the 21st Century
https://braincanada.ca/funded-grants/garden-of-resilience-stories-of-disruption-and-adaptation-during-the-21st-centuryIn the era of climate change-related disasters and a globally disruptive pandemic, people worldwide are grappling with the question of how to foster resilience. Project Overview In the era of climate change-related disasters and a globally disruptive pandemic, people worldwide are grappling with...
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Generating expanded repeats in the C9ORF72 ortholog in zebrafish
https://braincanada.ca/funded-grants/generating-expanded-repeats-in-the-c9orf72-ortholog-in-zebrafishOver the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments. Project Overview Over the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments. To...
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Genes involved in APP-mediated GLUT1 regulation
https://braincanada.ca/funded-grants/genes-involved-in-app-mediated-glut1-regulationAlzheimer’s disease is the most common form of dementia. Project Overview Alzheimer’s disease is the most common form of dementia. The brains of many of the patients are less well supplied with glucose (sugar), but not much research aims to understand why this happens. Further, a protein of central...
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Genetic and therapeutic dependencies in SHH driven childhood medulloblastoma
https://braincanada.ca/funded-grants/genetic-and-therapeutic-dependencies-in-shh-driven-childhood-medulloblastomaMedulloblastoma is the most common malignant brain tumour of childhood, affecting 60-80 Canadian children per year. Project Overview Medulloblastoma is the most common malignant brain tumour of childhood, affecting 60-80 Canadian children per year. The treatment for medulloblastoma comprises...
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Genome-wide discovery and clinical translation of tandem repeat expansions in brain disorders
https://braincanada.ca/funded-grants/genome-wide-discovery-and-clinical-translation-of-tandem-repeat-expansions-in-brain-disordersBrain disorders are among the leading causes of death and disability worldwide, affecting about 3.6 million Canadians. While we know that genetics play an important role, the specific genetic causes remain unknown for most people with the disorders. Project Overview Brain disorders are among the...
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Genomic dark matter behind brain disorders
https://braincanada.ca/about/news-updates/genomic-dark-matter-behind-brain-disordersDr. Yuen discovered and patented a method to detect tandem repeat expansions in complex brain disorders. He and his research team used this method to determine that tandem repeat expansions contribute to at least 3% of autism cases. New method identifies genomic dark matter behind complex brain...
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Genomic markers of cerebral small vessel ischemia
https://braincanada.ca/funded-grants/genomic-markers-of-cerebral-small-vessel-ischemiaThe overall goal of this research program is to identify genomic markers that predict small vessel disease of the brain. Project Overview The overall goal of this research program is to identify genomic markers that predict small vessel disease of the brain. Specifically we will investigate...
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Geometric Determinants of Hippocampal Spatial Encoding
https://braincanada.ca/funded-grants/geometric-determinants-of-hippocampal-spatial-encodingOur brains have their own GPS – the hippocampus, a region where special neurons, called ‘place cells’, help us navigate and store memories. Project Overview Our brains have their own GPS – the hippocampus, a region where special neurons, called ‘place cells’, help us navigate and store memories....