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Investigating the templated propagation and impact of pathogenic FUS in hiPSCs-derived cerebral organoids
https://braincanada.ca/funded-grants/investigating-the-templated-propagation-and-impact-of-pathogenic-fus-in-hipscs-derived-cerebral-organoidsAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle weakness and ultimately paralysis. Project Overview Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle...
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Investigating the Templated Propagation of the ALS-related Protein FUS in iPSC-derived Cerebral Organoids
https://braincanada.ca/funded-grants/investigating-the-templated-propagation-of-the-als-related-protein-fus-in-ipsc-derived-cerebral-organoidsAmyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and paralysis, partly due to the buildup of protein aggregates in nerve cells. Project Overview Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes muscle weakness and...
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Investigating therapeutic approaches for SPTLC1 ALS variants using zebrafish models
https://braincanada.ca/funded-grants/investigating-therapeutic-approaches-for-sptlc1-als-variants-using-zebrafish-modelsWhile most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children. Project Overview While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1...
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Investigating Trans-acting Genetic Modifier Variants’ Association with Loss of Interruption (LOI) Variants and Impacts on Age of Onset in Relation to Canonical Alleles.
https://braincanada.ca/funded-grants/investigating-trans-acting-genetic-modifier-variants-association-with-loss-of-interruption-loi-variants-and-impacts-on-age-of-onset-in-relation-to-canonical-allelesHuntington’s disease (HD) age of onset is primarily determined by the CAG repeat length in the huntingtin gene (HTT); however, CAG repeat length does not fully explain the variability in age of onset observed between HD affected individuals. Approximately a dozen HD genetic modifiers have been...
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Investigation of Cerebrovascular Disease across Sexes and Neurodegenerative Disorders through Post-mortem Imaging and Histology
https://braincanada.ca/funded-grants/investigation-of-cerebrovascular-disease-across-sexes-and-neurodegenerative-disorders-through-post-mortem-imaging-and-histologyOver 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. Project Overview Over 600,000 Canadians currently live with different types of dementia, and more than 76,000 new dementia cases are diagnosed each year. In over...
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Investigation of DNA damage response as a genomic modifier in Rett syndrome
https://braincanada.ca/funded-grants/investigation-of-dna-damage-response-as-a-genomic-modifier-in-rett-syndromeRett syndrome is a severe neurological disorder that is caused by genetic mutations in the MECP2 gene. Project Overview Rett syndrome is a severe neurological disorder that is caused by genetic mutations in the MECP2 gene. The disorder almost exclusively affects females, presents in childhood and...
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Investigation of microbiota mediated suppression of motor neuron degeneration in genetic models of ALS
https://braincanada.ca/funded-grants/investigation-of-microbiota-mediated-suppression-of-motor-neuron-degeneration-in-genetic-models-of-alsScientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape. Project Overview Scientists have long wondered what the contribution of environment is to ALS and in...
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Investigation of neuroinflammation and microglial subtypes associated with ALS
https://braincanada.ca/funded-grants/investigation-of-neuroinflammation-and-microglial-subtypes-associated-with-alsThe common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is neuronal death. Project Overview The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD),...
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Investigation of the innate immune system and motor neuron degeneration in genetic models of ALS
https://braincanada.ca/funded-grants/investigation-of-the-innate-immune-system-and-motor-neuron-degeneration-in-genetic-models-of-alsIn recent years, it was discovered that a microscopic worm called C. elegans could mimic some of the aspects of human ALS when they were engineered to have abnormal (mutant) genes that cause the disease. Project Overview In recent years, it was discovered that a microscopic worm called C. elegans...
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Investing in Mental Health Research in Diabetes
https://braincanada.ca/about/news-updates/investing-in-mental-health-research-in-diabetesBrain Canada and The ALS Society of Canada (ALS Canada) are proud to announce the recipients of the 2025 ALS Canada–Brain Canada Clinical Research Fellowship and Trainee Awards. Brain Canada and Diabetes Canada are pleased to announce funding for two research projects at the intersection of...
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