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Challenge: Delivery of therapeutic proteins to the brain has been a longstanding barrier to CNS drug development. Project Overview Challenge: Delivery of therapeutic proteins to the brain has been a longstanding barrier to CNS drug development. Protein replacement or supplementation strategies hold...

Taufik Valiante, Ph. D. Brain Canada’s vision of science without barriers or borders is promoting global thought and connections. Innovation does not hold a passport or recognize frontiers. Science knows no nation. The understanding of the brain, in health and in illness, requires knowledge,...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately death. Project Overview Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor...

Individuals with an incurable condition marked by decline and intolerable suffering and where death is reasonably foreseeable, as with dementia, now have access to medical assistance in dying (MAID). Project Overview Individuals with an incurable condition marked by decline and intolerable...

The LINGO-1 protein is strongly associated with Alzheimer’s disease and is a novel drug target. Project Overview The LINGO-1 protein is strongly associated with Alzheimer’s disease and is a novel drug target. LINGO-1 is a transmembrane protein that negatively regulates neuronal survival and...

Neurological and psychiatric diseases and disorders affect more than half the population. Project Overview Neurological and psychiatric diseases and disorders affect more than half the population. These disorders of the nervous system can span a range of illnesses, including generalized anxiety...

Ependymal cells are a largely understudied barrier cell type in the brain that provide a wall between brain tissue and brain fluid (cerebral spinal fluid, CSF), playing an important role in regulating fluid balance. Project Overview Ependymal cells are a largely understudied barrier cell type in...

When Naomi Azrieli, O.C., DPhil, first stepped into the role of Chair of Brain Canada, she brought with her not only deep philanthropic experience, but a profound belief in what bold scientific inquiry could make possible. Over the next eight years, that conviction helped fuel a period of...

Nicole Hagley, an educator, past national athlete, and now yoga instructor, is still actively recovering from a bike accident two years ago. “We need people to understand the diversity of the brain, and the fact that no two brain injuries are the same.” “Even though you have an amazing circle of...

Ischemic stroke, caused by a blood clot in the brain, is a leading cause of death, disability, and dementia. Project Overview Ischemic stroke, caused by a blood clot in the brain, is a leading cause of death, disability, and dementia. One in four of these strokes happens in patients who already had...