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859 results found

Selection of DNA Aptamers for Inhibition of Protein Aggregation in ALS

The fight against ALS is made extremely challenging due to its largely unknown origin in most patients.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2025

Early Intervention for Youth Suicide: Leveraging EEG to Predict Treatment Response and Suicidality in the TIDE Trial

Depression is one of the most common mental health challenges faced by young people, yet choosing the right treatment remains a process of trial and error.


Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2025

Stress granules: neuroprotective or neurotoxic in ALS pathogenesis?

ALS is a devastatingly fatal neurodegenerative disease with patients losing their ability to walk, talk, eat, and interact with their loved ones.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025

Studying the involvement of cell surface RNA binding proteins in ALS pathogenesis

Amyotrophic lateral sclerosis (known as ALS or Lou Gehrig’s disease) is a debilitating disease that causes loss of control over muscles and leads to death quickly after diagnosis.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025

Single-cell multi-omics to uncover mechanisms of patient glioblastoma heterogeneity and recurrence

Brain cancer is rarely curative and urgently needs novel transformative treatments.


Grant type
Capacity building grants
Area of Research
Cancer
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2025

Investigating the templated propagation and impact of pathogenic FUS in hiPSCs-derived cerebral organoids

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle weakness and ultimately paralysis.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025

Investigating therapeutic approaches for SPTLC1 ALS variants using zebrafish models

While most forms of ALS occur in adulthood, mutations in the gene termed Serine Palmitoyltransferase Long Chain Base Subunit 1 (SPTLC1) arise in children.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025

Investigating Myelin Modulation by Psychoplastogens as a Novel Mechanism for Sustained Therapeutic Outcomes in Neuropsychiatric Disorders

Psychedelic drugs, known for their profound effects on perception, are showing promise as rapid and long-lasting treatments for depression.


Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2025

Late stage pre‐clinical development of a small molecule compound for re‐myelination and functional recovery in multiple sclerosis through disruption of the AMPA‐GAPDH complex

While it is the immune system that damages the brain in MS, the way this damage is caused involves many processes.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
Therapeutic Development Opportunities Addressing MS
Province
Ontario
Start Date
2025

Evaluating the role of intestinal inflammation in Alzheimer’s Disease

Recent findings suggest that the gut and brain are closely connected, and this link may be important in Alzheimer’s disease (AD).


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Alzheimer Society Research Program (ASRP)
Province
Ontario
Start Date
2025