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886 results found

Targeting GRP78 palmitoylation in glioblastomas

Glioblastoma multiforme (GBM) the most common form of brain cancer in adults with very low survival of only 15 months with less than 5% of patients surviving more than 5 years. Surgery, chemotherapy, and radiation are the treatments currently used but recurrence is very common, often with tumors that are resistant to treatment.


Grant type
Capacity building grants
Area of Research
Cancer
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2022

Evaluating an innovative e-mental health solution to support youth with mental health disorders in Northwestern Ontario

Many youth suffer from mental health-related brain disorders which can have devastating consequences Effective treatment is desperately needed.


Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2022

Investigating the role of microglia in brain disorders, by high-throughput single-cell screening of disease-associated genes in human immuno-competent brain avatars

Most brain disorders remain incurable, whether they begin during early development, as seen in Autism, or seem acquired over time, as observed in Alzheimer’s disease.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2022

Defining the role of primary cilia in shaping astrocyte development and response to brain insults

Astrocytes are a major type of cells that react to brain activity, injuries and diseases to help support optimal brain functions.


Grant type
Capacity building grants
Area of Research
Injury
Competition
Future Leaders in Canadian Brain Research
Province
Alberta
Start Date
2022

Characterizing functional brain connectivity in critically ill children at-risk for delirium

A significant proportion of critically ill children experience delirium, a form of brain dysfunction associated with adverse outcomes.


Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2022

Uncover regulators of key glioblastoma cell states and test their therapeutic potential

Tumors continuously change towards more aggressive and resistant forms.


Grant type
Capacity building grants
Area of Research
Cancer
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2022

An identity crisis of satiety neurons: how prolonged metabolic stress can reprogram the hypothalamus

The prevalence of obesity has reached pandemic levels and represents a massive societal and economic burden.


Grant type
Capacity building grants
Area of Research
Other
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2022

Antenatal prediction of preterm birth: placental function, fetal and neonatal brain development

Fetal growth restriction is associated with pregnancy complications, as well as high rates of preterm birth and childhood disabilities.


Grant type
Capacity building grants
Area of Research
Neurodevelopment
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2022

Remote Ischemic Preconditioning to promote CNS remyelination

In Multiple Sclerosis (MS), new brain lesions appear because of inflammation and loss of myelin (the structure covering nerves).


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Alberta
Start Date
2022

Microbiota-Microglia Interactions in Pediatric Inflammatory Bowel Disease

Despite the recent advances in our understanding between the connection between the microbes living in the gut and our mental health, there remains a wide knowledge gap in understanding how the brain is negatively impacted in disorders with inflammation of the gut.


Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Future Leaders in Canadian Brain Research
Province
British Columbia
Start Date
2022