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859 results found

Evaluating therapeutic stimulation in a mouse model of perinatal stroke

Neonatal strokes occur in approximately 1 in 1500 term births and is the leading cause of hemiplegic cerebral palsy (HCP).

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Injury
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2021

Investigating mechanisms that cause mitochondrial dysfunction and synaptic loss

Amyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s movement.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2021

Impaired orexin activity as a mediator of isolation-induced social anxiety

We live in a world profoundly shaped by social behaviours involving interactions and communications between conspecifics of a given species.

Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Future Leaders in Canadian Brain Research
Province
Alberta
Start Date
2021

Investigating Spike-Timing Dependent Plasticity Mechanisms of Memory Consolidation with Multiscale Hippocampal-Cortical Modelling

The formation of our memories is a behaviour that encapsulates both long-and-short time scales.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Future Leaders in Canadian Brain Research
Province
Alberta
Start Date
2021

Investigating the molecular chaperone DNAJA2 as an inhibitor of tau aggregate pathology in Alzheimer’s

Alzheimer’s Disease is a progressive and fatal disease that currently afflicts up to 400,000 Canadians over the age of 65.

Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Alberta
Start Date
2021

Closed-loop deep brain stimulation using chronic intracranial cortical sensing to inform subcortical stimulation delivery

Many people with Parkinson’s disease have trouble with freezing of gait (FoG), a symptom that causes them to stop walking unexpectedly and makes them more likely to fall.

Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2021

Cognition and Functional Specialization in Connectome-Based Neuromorphic Networks

How does the wiring of the brain confer cognitive capacity?

Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2021

Challenging epigenetic hallmarks of aging in the choroid plexus to improve brain homeostasis

The choroid plexus (CP) is a secretory tissue found in each of the brain ventricles.

Project ongoing See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2021

Understanding how deviations in postnatal hippocampal neurogenesis and circuit activity contribute to bipolar disorder with patient-derived pluripotent stem cells

The brain is vulnerable to many disorders that can strike at every stage of life.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodevelopment
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2021

Circadian control of microglial activation in chronic pain states

Circadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body temperature control the best known examples.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2021