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853 results found

Screening of glioblastoma oncometabolite by ultrafast solid phase microextraction approach

Need for project: The rate of success of a given treatment for brain cancer is dependent on early diagnosis followed by qualification for surgery, which to date remains as the course of treatment with the highest survival rate for brain cancer patients.


Grant type
Team grants
Area of Research
Cancer
Competition
CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection
Province
Ontario
Start Date
2021

Detection and prevention of pypermutant glioma in children and young adults

Need for project: Replication repair deficiency (RRD) is a genetic condition that significantly increases the risk of developing cancer, particularly early in life.


Grant type
Team grants
Area of Research
Cancer
Competition
CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection
Province
Ontario
Start Date
2021

Advanced multi-functional in vivo retinal imaging for ocular oncology

Need for project: Choroidal tumors present clinicians with many challenges. The overlap between clinical and imaging findings combined with the difficulty of performing choroidal biopsies can create diagnostic dilemmas.


Grant type
Team grants
Area of Research
Cancer
Competition
CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection
Province
British Columbia
Start Date
2021

Physical fingerprints of single extracellular vesicles for liquid biopsy in brain cancer

Need for project: Glioblastoma (GBM) is an incurable brain cancer that changes rapidly confounding standard diagnostic and therapeutic methods.


Grant type
Team grants
Area of Research
Cancer
Competition
CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection
Province
Québec
Start Date
2021

Radiomics and machine learning based non-invasive biomarkers for prediction of peritumoral invasion in brain metastases

Need for project: Treatment of brain metastases (BrM) includes a combination of surgery and radiation therapy (RT).


Grant type
Team grants
Area of Research
Cancer
Competition
CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection
Province
Québec
Start Date
2021

Precision diagnosis and prognosis of primary and metastatic brain tumours using DNA methylation profiling in liquid biopsy

Need for project: More sensitive molecular tools are needed in the field of neuro-oncology to enable early detection, more accurate diagnosis, and prediction of outcome for brain tumors.


Grant type
Team grants
Area of Research
Cancer
Competition
CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection
Province
Ontario
Start Date
2021

Early diagnosis of gliomas by using a novel multiplexed serum proteomic technology

Need for project: Gliomas are among the most malignant tumors, with very poor survival rates.


Grant type
Team grants
Area of Research
Cancer
Competition
CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection
Province
Québec
Start Date
2021

Safety and feasibility of focused ultrasound-enabled liquid biopsy in patients with brain tumours

Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of morbidity or mortalityto patients.


Grant type
Team grants
Area of Research
Cancer
Competition
CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection
Province
Ontario
Start Date
2021

Mutations in the gene encoding the molecular chaperones DnaJC7 in amyotrophic lateral sclerosis

In 2019, a team of scientists led by co-recipient Dr. Sali Farhan discovered a new genetic cause of ALS called DNAJC7.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2021

Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS

Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2021