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859 results found

Investigating the role of mutations in CHCHD10 using ALS cell and zebrafish genetic models

CHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood.

Project completed See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2021

Advanced pharmacokinetics and pharmacodynamics for phase Ib/IIa trial of repurposed enoxacin therapy for patients with ALS

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, primarily affecting motor neurons, for which there are currently no adequately effective therapies.

Project ongoing See Project & Researchers
Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2021

Mapping neuronal circuits using a novel transsynaptic labelling approach

The brain is more than the sum of its parts.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2020

Molecular origins of childhood brain cancer

Pediatric high-grade gliomas are incurable brain cancers.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Cancer
Competition
Future Leaders in Canadian Brain Research
Province
Alberta
Start Date
2020

Individually Tailored Prediction of Treatments Response in Alzheimer’s Disease: 3 clinical trials validation

Late-onset Alzheimer’s (late-AD) is a complex neurodegenerative condition with abnormalities in toxic protein accumulation, vascularization, inflammation, neuronal activity and cerebral atrophy.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2020

Molecular and behavioural assessment of a potential fetal Cannabis spectrum disorder in the rat

Canada recently became the first G7 nation to legalize Cannabis for medicinal and recreational use.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodevelopment
Competition
Future Leaders in Canadian Brain Research
Province
Saskatchewan
Start Date
2020

Relating hippocampal pathways to human learning

The human experience is marked by constant learning.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2020

The endocannabinoid system: a master regulator of brain and gut health in mood disorders

Depression will affect 1 out of 5 individuals in their lifetime.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2020

Investigation of neuroinflammation and microglial subtypes associated with ALS

The common end stage pathology of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) is neuronal death.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2020

Neuroprosthetic-mediated rehabilitation of autonomic function after spinal cord injury

Spinal cord injury (SCI) is a devastating medical condition that forever changes the trajectory of life.

Project completed See Project & Researchers
Grant type
Capacity building grants
Area of Research
Injury
Competition
Future Leaders in Canadian Brain Research
Province
Alberta
Start Date
2020