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839 results found

Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

Each muscle in the body receives electrical signals through motor neurons that will stimulate it to contract.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Québec
Start Date
2018

Characterizing Enterovirus Disruption of Autophagy as a Disease Mechanism for ALS

A group of viruses called enteroviruses can cause a variety of infectious illnesses that are usually mild with symptoms that may include fever, respiratory distress, flu-like muscle aches and rashes.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
British Columbia
Start Date
2018

Investigating the effects of C9orf72 haploinsufficiency on TDP-43 pathology in ALS

Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Ontario
Start Date
2018

MRI Biomarkers of Cerebral Degeneration in ALS and their Pathological Validation

A biological marker, or “biomarker” for short, is a measurable indicator associated with a disease state that helps determine risk, severity and response to therapy.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Alberta
Start Date
2018

The Canadian Prospective Cohort Study to Understand Progression in Multiple Sclerosis (CanProCo)

Progression – or the steady worsening of disease and increase in disability – is a challenging reality faced by people affected by MS, and despite major advances in MS research, the mechanism of progression and the ways in which researchers and clinicians can track progression are still not fully understood.


Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
MS Progression Cohort
Province
Ontario
Start Date
2018

Canadian Open Parkinson Network (C-OPN)

The Canadian Open Parkinson Network, or C-OPN, is a national network that unites researchers, physicians and patients across Canada to study Parkinson’s disease (PD).


Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
Other
Province
Alberta
Start Date
2018

A Drug Screening Platform to Increase Protein Expression Levels for Treatment of Neurological Disorders

Neurological and psychiatric diseases and disorders affect more than half the population.


Grant type
Platform grants
Area of Research
Neurotechnology
Competition
CQDM - Brain Canada - Quantum Leap
Province
Québec
Start Date
2018

Assistive technology for cognition to increase safety at home

Maintaining the ability to prepare meals independently in Alzheimer’s disease (AD) is of paramount importance to the individuals themselves and to their caregivers.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Alzheimer's Association Research Grant
Province
Québec
Start Date
2018

Dysregulation of integrated stress response (ISR) pathway in Fragile X syndrome and autism

Mr. Hooshmandi’s research will examine the hypothesis that reduced phosphorylation of eIF2α excessively stimulates general translation in Fmr1 KO mice during brain development, contributing to the pathophysiology of Fragile X syndrome (FXS) and potentially of other forms of autism.


Grant type
Capacity building grants
Area of Research
Neurodevlopment
Competition
Brain Canada - Kids Brain Health Network Training Awards
Province
Québec
Start Date
2018

Sex differences in exercise efficacy: Possible role of BDNF and stress axis

Research suggests that exercise can help improve brain health and decrease the risk of dementia, but there is variation in the benefit of different exercise interventions.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Alzheimer's Association Research Fellowship
Province
British Columbia
Start Date
2018