Funded Grants

Need for project: Gliomas are among the most malignant tumors, with very poor survival rates.

Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of morbidity or mortalityto patients.

In 2019, a team of scientists led by co-recipient Dr. Sali Farhan discovered a new genetic cause of ALS called DNAJC7.

Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS.

Recently, Dr. Honglin Luo, in collaboration with Dr. Neil Cashman, discovered that mutations in the ALS-linked SOD1 gene result in activation of a specific neuroinflammatory pathway called cGAS-STING.

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease with distinct genetic contributions.

Amyotrophic Lateral Sclerosis (ALS) is very much a disease of losses and adjustments.

Mutations in a gene called C9ORF72 are the most common genetic cause of ALS. These mutations are unique in that unlike most other ALS-linked genes, where there is often a mistake in a single piece of DNA, C9ORF72 mutations involve a section of DNA that is abnormally repeated hundreds or even thousands of times.

CHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood.

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, primarily affecting motor neurons, for which there are currently no adequately effective therapies.