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799 results found

Hippocampal heterogeneity in health and disease

The brain is estimated to contain 100 billion cells that form 100 trillion connections.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Azrieli Foundation - Brain Canada Early-Career Capacity Building grants
Province
Newfoundland and Labrador
Start Date
2018

The influence of functional connectivity on cognitive reserve

Declining cognitive activity is associated with a wide-variety of neurodegenerative disorders, brain injuries as well as with normal aging despite any clear pathological condition.


Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Azrieli Foundation - Brain Canada Early-Career Capacity Building grants
Province
Alberta
Start Date
2018

Nociceptor neurons control cancer immunosurveillance

Dr. Talbot studies the dialogue between the nervous and immune systems.


Grant type
Capacity building grants
Area of Research
Cancer
Competition
Azrieli Foundation - Brain Canada Early-Career Capacity Building grants
Province
Québec
Start Date
2018

Mapping the cellular origins of circuit vulnerability in neurodevelopmental disorders

The brain is an incredibly complex organ. Much of the brain’s complexity may be attributed to the circuitry that resides within.


Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Azrieli Foundation - Brain Canada Early-Career Capacity Building grants
Province
Ontario
Start Date
2018

Detection of misfolded TDP-43 in CSF of ALS cases: Diagnostic potential of confirmation-specific antibodies

A more streamlined way to diagnose ALS earlier is desperately needed as current methods can take up to two years and rely heavily on ruling out other conditions that share similar symptoms.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Ontario
Start Date
2018

Pre-clinical drug discovery against hexanucleotide repeat-containing C9orf72 toxicity using Caenorhabditis elegans and patient-derived induced motor neurons

A few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor neuron degeneration and paralysis.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Québec
Start Date
2018

Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

Each muscle in the body receives electrical signals through motor neurons that will stimulate it to contract.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Québec
Start Date
2018

Characterizing Enterovirus Disruption of Autophagy as a Disease Mechanism for ALS

A group of viruses called enteroviruses can cause a variety of infectious illnesses that are usually mild with symptoms that may include fever, respiratory distress, flu-like muscle aches and rashes.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
British Columbia
Start Date
2018

Investigating the effects of C9orf72 haploinsufficiency on TDP-43 pathology in ALS

Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Ontario
Start Date
2018

MRI Biomarkers of Cerebral Degeneration in ALS and their Pathological Validation

A biological marker, or “biomarker” for short, is a measurable indicator associated with a disease state that helps determine risk, severity and response to therapy.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Alberta
Start Date
2018