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853 results found

Investigation of microbiota mediated suppression of motor neuron degeneration in genetic models of ALS

Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2017

Decoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2017

Proteomic and Transcriptomic Profiling of Paraspeckle Function in Healthy and ALS Model Neuronal Cells

Over the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded considerably.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2017

A patient-derived iPSC platform of disease relevant cell models for biological studies

One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs).


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Québec
Start Date
2017

Quantitative MRI as a biomarker of tumour resistance to radiation treatment in brain metastasis

Brain metastasis occurs in 20% to 40% of all cancer patients and impacts quality of life and survival. Stereotactic radiosurgery (SRS), which involves delivering high doses of radiation to the tumour, is the preferred treatment for these patients.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Ontario
Start Date
2017

Pathogenic Mechanism of C9orf72 haploinsufficiency in ALS/FTLD: a road to therapeutic discovery

In this Hudson project, the team led by Dr. Robertson will pursue a comprehensive understanding of the normal functions of C9ORF72 and provide a better determination of whether loss of these functions via mutation may cause or contribute to ALS.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Ontario
Start Date
2017

Advancing biology based therapies for rhabdoid brain tumours

Rhabdoid brain tumours are the most common brain cancers in infants.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Training Grants
Province
Ontario
Start Date
2017

Neuroinflammatory susceptibility to vascular disease as a dementia driver

Recent studies have shown that damage to the small blood vessels in the brain (cerebrovascular disease) may increase the risk for Alzheimer’s.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Province
Ontario
Start Date
2017

The feasibility of hyperpolarized 13C-Pyruvate MRI for monitoring patients with intracranial metastasis

Surgery and radiation are standard treatments for cancer that has spread to the brain.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Ontario
Start Date
2017

Development of novel oligonucleotide delivery modalities for Huntington disease

Huntington disease (HD) is an inherited neurodegenerative disease that affects approximately 1 in 7500 individuals in the Western world.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
Brain Canada -Huntington Society of Canada HD Clinician-Scientist-to-Patent Virtual Networks Multi-Investigator
Province
British Columbia
Start Date
2017