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853 results found

Impaired Neuromuscular Junction Connectivity in Amyotrophic Lateral Sclerosis

Many scientists believe that one of the earliest abnormalities in ALS is dysfunction at the place where motor neurons connect to muscle, known as the neuromuscular junction (NMJ).


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
British Columbia
Start Date
2017

Sleep, cognition, and inflammation following natural or surgical menopause

Alzheimer’s disease disproportionately affects women and emerging evidence suggests there may be unique biological and lifestyle factors that underlie these differences.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Alzheimer's Association Research Fellowship
Province
Ontario
Start Date
2017

Montreal integrated neuropsychiatric cohort: Identifying subtypes of Autism and Schizophrenia integrating genomics, endophenotypes, and cohorts of high-risk genetic variants

Autism spectrum disorders (ASD) and schizophrenia (SZ) are two psychiatric conditions that affect approximately 2% of the general population. Genetic studies have identified mutations in hundreds of genes associated with ASD and SZ.


Grant type
Team grants
Area of Research
Multiple
Competition
2015 MIRI Team Grants
Province
Québec
Start Date
2017

A patient-derived iPSC platform of disease relevant cell models for biological studies

One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs).


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Québec
Start Date
2017

Using synthetic antibody parts to construct antibody-based imaging devices – anti-EGFR molecular targeted imaging probes for diagnosing and monitoring glioblastoma

To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Saskatchewan
Start Date
2017

Decoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2017

Pathogenic Mechanism of C9orf72 haploinsufficiency in ALS/FTLD: a road to therapeutic discovery

In this Hudson project, the team led by Dr. Robertson will pursue a comprehensive understanding of the normal functions of C9ORF72 and provide a better determination of whether loss of these functions via mutation may cause or contribute to ALS.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Ontario
Start Date
2017

Quantitative MRI as a biomarker of tumour resistance to radiation treatment in brain metastasis

Brain metastasis occurs in 20% to 40% of all cancer patients and impacts quality of life and survival. Stereotactic radiosurgery (SRS), which involves delivering high doses of radiation to the tumour, is the preferred treatment for these patients.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Ontario
Start Date
2017

The feasibility of hyperpolarized 13C-Pyruvate MRI for monitoring patients with intracranial metastasis

Surgery and radiation are standard treatments for cancer that has spread to the brain.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Ontario
Start Date
2017

Integrative discovery of ion channels as drug targets in glioblastoma

Ion channel (IC) proteins are known to be involved in different human diseases such as heart and brain disorders.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Ontario
Start Date
2017