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887 results found

A patient-derived iPSC platform of disease relevant cell models for biological studies

One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs).


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Québec
Start Date
2017

Investigation of microbiota mediated suppression of motor neuron degeneration in genetic models of ALS

Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2017

Sleep, cognition, and inflammation following natural or surgical menopause

Alzheimer’s disease disproportionately affects women and emerging evidence suggests there may be unique biological and lifestyle factors that underlie these differences.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
Alzheimer's Association Research Fellowship
Province
Ontario
Start Date
2017

Proteomic and Transcriptomic Profiling of Paraspeckle Function in Healthy and ALS Model Neuronal Cells

Over the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded considerably.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2017

Defining conserved functions of RNA binding proteins in stress-granule biogenesis

RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2017

Pathogenic Mechanism of C9orf72 haploinsufficiency in ALS/FTLD: a road to therapeutic discovery

In this Hudson project, the team led by Dr. Robertson will pursue a comprehensive understanding of the normal functions of C9ORF72 and provide a better determination of whether loss of these functions via mutation may cause or contribute to ALS.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Arthur J. Hudson Translational Team Grant
Province
Ontario
Start Date
2017

Using synthetic antibody parts to construct antibody-based imaging devices – anti-EGFR molecular targeted imaging probes for diagnosing and monitoring glioblastoma

To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Saskatchewan
Start Date
2017

Molecular characterization of transcriptional repressor capicua in GBM

Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few effective treatment options.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Ontario
Start Date
2017

Montreal integrated neuropsychiatric cohort: Identifying subtypes of Autism and Schizophrenia integrating genomics, endophenotypes, and cohorts of high-risk genetic variants

Autism spectrum disorders (ASD) and schizophrenia (SZ) are two psychiatric conditions that affect approximately 2% of the general population. Genetic studies have identified mutations in hundreds of genes associated with ASD and SZ.


Grant type
Team grants
Area of Research
Multiple
Competition
2015 MIRI Team Grants
Province
Québec
Start Date
2017

Integrative discovery of ion channels as drug targets in glioblastoma

Ion channel (IC) proteins are known to be involved in different human diseases such as heart and brain disorders.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Innovation Grants
Province
Ontario
Start Date
2017