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799 results found

Use of bone marrow cells to deliver single chain antibodies in ALS

This project will use cells found in bone marrow as a potential means of delivering treatments to the diseased area in brain and spinal cord.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
British Columbia
Start Date
2015

Epigenetic mechanisms underlying dendritic atrophy in ALS

Motor neurons are made up of three distinct regions. The top of the neuron is composed of branches like a tree called dendrites that receive information to transmit.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2015

The interplay of DNA regulatory elements and epigenetics in Alzheimer’s disease

Alzheimer’s disease (AD) is a severely disabling illness with biological causes that are not well understood. Abnormalities in gene function impacts brain activities and could cause AD.


Grant type
Capacity building grants
Area of Research
Neurodevlopment
Competition
Alzheimer's Society Research Program (ASRP)/Brain Canada New Investigator & Career Change Grants
Province
Ontario
Start Date
2015

Novel Cellular and Molecular Mechanisms Regulating Synapse Dysfunction in Alzheimer’s Disease

In Alzheimer s disease (AD), critical synaptic connections between neurons disintegrate and cells die.


Grant type
Capacity building grants
Area of Research
Neurodevlopment
Competition
Alzheimer's Society Research Program (ASRP)/Brain Canada New Investigator & Career Change Grants
Province
Québec
Start Date
2015

Locally produced brain insulin in memory and Alzheimer’s disease: A multi-disciplinary approach to a key question

One percent of Alzheimer’s disease is the early-onset type that runs in families.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
BC Alzheimer's Research Award Program
Province
British Columbia
Start Date
2015

Novel Retinal Biomarkers for Alzheimer’s Disease

Individuals with Alzheimer’s suffer severe memory loss over time, and eventually are completely dependent on caregivers.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
BC Alzheimer's Research Award Program
Province
British Columbia
Start Date
2015

Molecular heterogeneity drives the clinical behaviour of childhood medulloblastoma

Brain cancer is the most common type of solid cancer in children in Canada, and medulloblastoma is the most common malignant brain cancer of childhood.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Impact Grants
Province
Ontario
Start Date
2015

Targeting the telomere maintenance pathway for cancer diagnostics and therapeutics.

Cancer can exhibit relentless growth and relapse because of the enhanced protection of its chromosome ends.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Impact Grants
Province
Ontario
Start Date
2015

Oncolytic rhabdovirus immunotherapy for brain cancer

Dr David Stojdl’s lab has custom‑built an oncolytic virus biotherapy specifically for the treatment of the devastating brain cancer, glioblastoma multiforme (GBM).


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Impact Grants
Province
Ontario
Start Date
2015

Deciphering eEF2K biological functions for therapeutic targeting of neural tumours

In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be aggressive and hard to treat.


Grant type
Team grants
Area of Research
Cancer
Competition
Canadian Cancer Society Impact Grants
Province
British Columbia
Start Date
2015