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853 results found

Novel Repetitive Transcranial Magnetic Stimulation Paradigm to Reduce Cortical Hyperexcitability in Patients with ALS

ALS is a devastating neurological disease characterized by the progressive degeneration of motor neurons leading to paralysis and death.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2025

A multi-methods multi-site study of end-of-life care in individuals with ALS: goal concordance and caregiver perceptions

Amyotrophic lateral sclerosis (ALS) is a terminal disease of nerves and muscles. From the time of symptom onset, people with ALS live about 3-5 years.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2025

Distributed neural representations in confidence-guided reinforcement learning

Rodent models offer an opportunity to understand the computations performed in neural circuits at a much precise scale than using human neuroimaging.


Grant type
Capacity building grants
Area of Research
Central Nervous System
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2025

Exploring a therapeutic approach to promote neuronal function for ALS

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases which have overlap in pathological features and the genetic basis.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2025

Selection of DNA Aptamers for Inhibition of Protein Aggregation in ALS

The fight against ALS is made extremely challenging due to its largely unknown origin in most patients.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2025

Early Intervention for Youth Suicide: Leveraging EEG to Predict Treatment Response and Suicidality in the TIDE Trial

Depression is one of the most common mental health challenges faced by young people, yet choosing the right treatment remains a process of trial and error.


Grant type
Capacity building grants
Area of Research
Mental Health
Competition
Future Leaders in Canadian Brain Research
Province
Québec
Start Date
2025

Stress granules: neuroprotective or neurotoxic in ALS pathogenesis?

ALS is a devastatingly fatal neurodegenerative disease with patients losing their ability to walk, talk, eat, and interact with their loved ones.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025

Studying the involvement of cell surface RNA binding proteins in ALS pathogenesis

Amyotrophic lateral sclerosis (known as ALS or Lou Gehrig’s disease) is a debilitating disease that causes loss of control over muscles and leads to death quickly after diagnosis.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025

Single-cell multi-omics to uncover mechanisms of patient glioblastoma heterogeneity and recurrence

Brain cancer is rarely curative and urgently needs novel transformative treatments.


Grant type
Capacity building grants
Area of Research
Cancer
Competition
Future Leaders in Canadian Brain Research
Province
Ontario
Start Date
2025

Investigating the templated propagation and impact of pathogenic FUS in hiPSCs-derived cerebral organoids

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the human motor system, leading to muscle weakness and ultimately paralysis.


Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2025