Funded Grants

Impairments in social cognition (SC), such as difficulties in understanding emotions, social cues, and maintaining meaningful interactions, are key contributors to the loss of social inclusion and quality of life in individuals with neurodegenerative diseases (ND).

Regardless of disease etiology, ~97% of ALS patients display TDP-43 pathology. TDP-43 is an RNA-binding protein that is involved in the cellular stress response. Following a stressor, TDP-43 translocates to the cytosol and is thought to be protective. However, with chronic stress and/or ALS-relevant mutations TDP-43 is depleted from the nucleus by translocating to the cytosol, where it ultimately aggregates.

Investigating the role of EPG5 in Parkinson’s Disease pathogenesis

Sofia Gentile, a Master’s Student at University of Toronto, is investigating the role of immune cell activation in a rare and fatal neurodegenerative disease called progressive supranuclear palsy.

Jenna Hanrahan, a Doctoral Student at Memorial University of Newfoundland, aims to characterize the brain of a humanized mouse model of Huntington’s disease.

Feasibility RCT of a digital tool for management of bulbar disease in ALS.

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that damages nerve cells controlling movement, and many patients also experience major changes in how their bodies use energy.

The Role of Brain Endocannabinoid Metabolism in Social Anxiety Disorder and Social Stress

Neuromuscular diseases (NMDs) are rare conditions that affect nerves and muscles.