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Relating hippocampal pathways to human learning
https://braincanada.ca/funded-grants/relating-hippocampal-pathways-to-human-learningThe human experience is marked by constant learning. Project Overview The human experience is marked by constant learning. Moments of contention, when new experiences conflict with prior knowledge, often lead to the most meaningful learning. How do we successfully navigate these moments and gain...
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Relational end-of-life care for people living with dementia: Innovating education and supporting practice change
https://braincanada.ca/funded-grants/relational-end-of-life-care-for-people-living-with-dementia-innovating-education-and-supporting-practice-change“Dementia is now recognised as a terminal illness and a leading cause of death globally. People living with dementia (PLwD) in Canada suffer painful, undignified, and inhumane end-of-life (EOL) experiences. Project Overview “Dementia is now recognised as a terminal illness and a leading cause of...
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Relevance of stress granule dynamics to ALS pathogenesis in vivo
https://braincanada.ca/funded-grants/relevance-of-stress-granule-dynamics-to-als-pathogenesis-in-vivoAmyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective treatment. Project Overview Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective...
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Remote ischemic conditioning to mitigate neurodegeneration in Alzheimer Disease
https://braincanada.ca/funded-grants/remote-ischemic-conditioning-to-mitigate-neurodegeneration-in-alzheimer-diseaseWe need new ways to treat Alzheimer’s Disease (AD). People with AD are keen to try non-drug therapies but none are approved for treating AD. Remote ischemic conditioning (RIC) is a non-drug therapy that involves inflating and deflating blood pressure cuffs repeatedly in the arm or leg. Project...
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Remote Ischemic Preconditioning to promote CNS remyelination
https://braincanada.ca/funded-grants/remote-ischemic-preconditioning-to-promote-cns-remyelinationIn Multiple Sclerosis (MS), new brain lesions appear because of inflammation and loss of myelin (the structure covering nerves). Project Overview In Multiple Sclerosis (MS), new brain lesions appear because of inflammation and loss of myelin (the structure covering nerves). MS treatments stop...
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Remote ischemic preconditioning treatment in amyotrophic lateral sclerosis
https://braincanada.ca/funded-grants/remote-ischemic-preconditioning-treatment-in-amyotrophic-lateral-sclerosisRATIONALE: There are no effective disease modifying therapies for amyotrophic lateral sclerosis (ALS). Project Overview RATIONALE: There are no effective disease modifying therapies for amyotrophic lateral sclerosis (ALS). Complete understanding of the physiopathology of ALS is lacking, and...
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Repairing nerve cell connections in Alzheimer’s disease
https://braincanada.ca/funded-grants/repairing-nerve-cell-connections-in-alzheimer-s-diseaseThe loss of connections between nerve cells is an early indicator of Alzheimer’s disease. Project Overview The loss of connections between nerve cells is an early indicator of Alzheimer’s disease. The loss of these connections also causes difficulty thinking and processing information....
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Representation of decision variables by catecholamines during learning
https://braincanada.ca/funded-grants/representation-of-decision-variables-by-catecholamines-during-learningOur ability to learn is directly proportional to our ability to detect the difference between a prediction and its outcome. Project Overview Our ability to learn is directly proportional to our ability to detect the difference between a prediction and its outcome. Reinforcement learning theories,...
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Reprogramming cells to replace neurons damaged by ALS?
https://braincanada.ca/about/news-updates/reprogramming-cells-to-replace-neurons-damaged-by-alsMeet the junior researchers behind the 2022 ALS Canada – Brain Canada Trainee Awards. Dr. Hussein Ghazale is the recipient of a $165,000 ALS Canada – Brain Canada 2022 Trainee Award. Meet the junior researchers behind the 2022 ALS Canada – Brain Canada Trainee Awards Dr. Hussein Ghazale is the...
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Research Brings Relief: rTMS Access Expanded Across Ontario
https://braincanada.ca/about/news-updates/rtms-access-expanded-ontarioFor many people living with treatment-resistant depression – whose symptoms have not improved with antidepressant medications or psychotherapy – repetitive transcranial magnetic stimulation (rTMS) can be life-changing. Some describe it as a fog finally being lifted. Some say it’s like their eyes...