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Researchers discover a protein responsible for shaping the nervous system
https://braincanada.ca/about/news-updates/researchers-discover-a-protein-responsible-for-shaping-the-nervous-systemTORONTO – A team of researchers led by The Hospital for Sick Children (SickKids), the University of Toronto (U of T) and Cold Spring Harbor Laboratory have discovered a protein that is responsible for shaping the nervous system. This research was made possible with the support of a $1.5-million...
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Resetting Microglia Activation in Offspring Exposed to Maternal High-Fat Diet
https://braincanada.ca/funded-grants/resetting-microglia-activation-in-offspring-exposed-to-maternal-high-fat-dietNutrition and diet are factors in life that contribute drastically to a person’s brain health, and overall quality of life, and high-fat diets can be considered a cause of many harmful physical and cognitive conditions. Project Overview Nutrition and diet are factors in life that contribute...
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Reshaping Mitochondrial Efficiency and Integrity to Treat Parkinson’s Disease
https://braincanada.ca/funded-grants/reshaping-mitochondrial-efficiency-and-integrity-to-treat-parkinson-s-diseaseParkinson’s Disease (PD) is a debilitating neurodegenerative disease for which there is no cure. Project Overview Parkinson’s Disease (PD) is a debilitating neurodegenerative disease for which there is no cure. This movement disorder is thought to be due to the loss of a specific population of...
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Restoration of mitochondrial function by activation of the NAD+/Sirtuin pathway to treat PD
https://braincanada.ca/funded-grants/restoration-of-mitochondrial-function-by-activation-of-the-nad-sirtuin-pathway-to-treat-pdParkinson’s Disease (PD) is a debilitating neurodegenerative disease for which there is no cure. Project Overview Parkinson’s Disease (PD) is a debilitating neurodegenerative disease for which there is no cure. The cardinal motor symptoms of PD are caused by the massive loss of neurons in a region...
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Restoration of visual function: a cellular reprogramming and bioengineering approach
https://braincanada.ca/funded-grants/restoration-of-visual-function-a-cellular-reprogramming-and-bioengineering-approachThe retina is the part of the eye that is responsible for processing visual information. Project Overview The retina is the part of the eye that is responsible for processing visual information. Loss of neurons (nerve cells) in the central nervous system, which includes the brain and retina, is a...
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Restoring Cerebrovascular Health in Alzheimer’s Disease by Targeting Molecular Damage in the Neurovascular Unit
https://braincanada.ca/funded-grants/restoring-cerebrovascular-health-in-alzheimer-s-disease-by-targeting-molecular-damage-in-the-neurovascular-unitAlzheimer’s disease is linked to the build-up of harmful proteins in the brain and damage to brain blood vessels. In many people, especially in later life, this build-up happens because the brain cannot clear these proteins effectively. Our research focuses on understanding how aging damages the...
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Restoring Hippocampal Disinhibition to Reverse Early Memory Deficits in Alzheimer’s Disease
https://braincanada.ca/funded-grants/restoring-hippocampal-disinhibition-to-reverse-early-memory-deficits-in-alzheimer-s-diseaseAlzheimer’s disease can affect memory and thinking by changing how brain cells communicate. Our project looks at early changes in the hippocampus, a part of the brain important for learning and memory. Project Overview Alzheimer’s disease can affect memory and thinking by changing how brain cells...
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Review process for the 2018 Early-Career Capacity Building Grants Program
https://braincanada.ca/about/news-updates/review-process-for-the-2018-early-career-capacity-building-grants-programAt Brain Canada, we want to ensure full transparency about our review process. The applications for this grants program were evaluated in person by a review panel composed of Canadian and International scientific experts as well as external reviewers, when needed. Reviewers evaluated and scored...
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RGNEF modulates protein misfolding in ALS
https://braincanada.ca/funded-grants/rgnef-modulates-protein-misfolding-in-alsDiscoveries made in Canada by the lab of Dr. Michael Strong over the past few years have implicated a protein called Rho guanidine nucleotide exchange factor (RGNEF) both pathologically and genetically in causing ALS. Project Overview Discoveries made in Canada by the lab of Dr. Michael Strong over...
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Rising Star Award in Mental Health Research, in memory of Vivian Distler
https://braincanada.ca/funded-grants/rising-star-award-in-mental-health-research-in-memory-of-vivian-distlerPersonalized Modeling and Optimization of Transcranial Temporal Interference Stimulation in Major Depressive Disorder Project Overview Personalized Modeling and Optimization of Transcranial Temporal Interference Stimulation in Major Depressive Disorder Depression affects nearly 2 million...