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Propagated protein misfolding of SOD1 in ALS: Exemplar for neurodegeneration
https://braincanada.ca/funded-grants/propagated-protein-misfolding-of-sod1-in-als-exemplar-for-neurodegenerationAmyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive fatal disease that affects the nerve cells responsible for muscle movement (motor neurons). Project Overview Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive fatal...
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Proteomic and Transcriptomic Profiling of Paraspeckle Function in Healthy and ALS Model Neuronal Cells
https://braincanada.ca/funded-grants/proteomic-and-transcriptomic-profiling-of-paraspeckle-function-in-healthy-and-als-model-neuronal-cellsOver the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded considerably. Project Overview Over the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded...
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Proteomic associations with brain and cognitive health and their interactions with modifiable risk factors for dementia
https://braincanada.ca/funded-grants/proteomic-associations-with-brain-and-cognitive-health-and-their-interactions-with-modifiable-risk-factors-for-dementiaAs people live longer, our society undergoes rapid demographic change. Project Overview As people live longer, our society undergoes rapid demographic change. Dementia and cognitive impairment in older adults poses a greater challenge to our healthcare system, affecting patients and caregivers....
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Prototype NIR Ca2+ indicators into refined tools that can be applied for neuronal activity imaging in model organisms
https://braincanada.ca/funded-grants/prototype-nir-ca2-indicators-into-refined-tools-that-can-be-applied-for-neuronal-activity-imaging-in-model-organismsOne of the major challenges facing the BRAIN initiative is the development of technologies that will enable the recording of neural activity throughout the entire volume of a rodent brain. Project Overview One of the major challenges facing the BRAIN initiative is the development of technologies...
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Psychological health and wellness among medical doctors in Canada and the impact of the Wellness4MDs supportive text messaging program.
https://braincanada.ca/funded-grants/psychological-health-and-wellness-among-medical-doctors-in-canada-and-the-impact-of-the-wellness4mds-supportive-text-messaging-programThis project’s main aim is to create and test a daily text messaging program called Wellness4MDs to help doctors, medical trainees, and students in Canada deal with burnout, anxiety, and depression. Project Overview This project’s main aim is to create and test a daily text messaging program called...
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Pushing boundaries in medical imaging to explore new pathways for ALS treatment
https://braincanada.ca/about/news-updates/pushing-boundaries-in-medical-imaging-to-explore-new-pathways-for-als-treatment“The idea is to not only diagnose but also to help in developing targeted treatments.” – Dr. Freimut Juengling Neurological imaging has advanced by leaps and bounds in the past two decades. Researchers can now “see” details of biological processes at a level never previously imagined. But we still...
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Pushing the boundaries of autism research
https://braincanada.ca/about/news-updates/pushing-the-boundaries-of-autism-research -
Quantitative fluorescence spectroscopy of the central nervous system amylome
https://braincanada.ca/funded-grants/quantitative-fluorescence-spectroscopy-of-the-central-nervous-system-amylomeIt is generally acknowledged that accumulation of misfolded proteins (amyloid) in brains of Alzheimer’s disease patients is a key disease phenomenon. Project Overview It is generally acknowledged that accumulation of misfolded proteins (amyloid) in brains of Alzheimer’s disease patients is a key...
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Quantitative MRI as a biomarker of tumour resistance to radiation treatment in brain metastasis
https://braincanada.ca/funded-grants/quantitative-mri-as-a-biomarker-of-tumour-resistance-to-radiation-treatment-in-brain-metastasisBrain metastasis occurs in 20% to 40% of all cancer patients and impacts quality of life and survival. Stereotactic radiosurgery (SRS), which involves delivering high doses of radiation to the tumour, is the preferred treatment for these patients. Project Overview Brain metastasis occurs in 20% to...
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Quantitative PET/MR Imaging of Brain Derived Neurotrophic Factor (BDNF) / Tropomyosin Related Kinase B (TRKB) signaling in ALS – decoding a potential pathogenetic pathway
https://braincanada.ca/funded-grants/quantitative-pet-mr-imaging-of-brain-derived-neurotrophic-factor-bdnf-tropomyosin-related-kinase-b-trkb-signaling-in-als-decoding-a-potential-pathogenetic-pathwayBrain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions, via activation of its high affinity receptor, tropomysin related kinase B (TrkB). Project Overview Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions, via...
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