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Real-life recall: An fMRI exploration of episodic memory in the real-world
https://braincanada.ca/funded-grants/real-life-recall-an-fmri-exploration-of-episodic-memory-in-the-real-worldMemory is a fundamental aspect of human cognition that allows us to remember past experiences that shape our future actions. Project Overview Memory is a fundamental aspect of human cognition that allows us to remember past experiences that shape our future actions. However, disorders such as...
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Recruitment of Endogenous Neural Stem Cells to Promote Brain Repair Following Acquired Brain Injury in Children
https://braincanada.ca/funded-grants/recruitment-of-endogenous-neural-stem-cells-to-promote-brain-repair-following-acquired-brain-injury-in-childrenIn Canada, over 140,000 children and teenagers suffer a brain injury each year due to trauma, stroke, cerebral palsy, and brain cancer. Project Overview In Canada, over 140,000 children and teenagers suffer a brain injury each year due to trauma, stroke, cerebral palsy, and brain cancer. Children...
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Regeneration Unit in Neurology: A platform for research and training in advanced microscopy and behavioural approaches
https://braincanada.ca/funded-grants/regeneration-unit-in-neurology-a-platform-for-research-and-training-in-advanced-microscopy-and-behavioural-approachesThe Regeneration Unit in Neurobiology (RUN) Core facility is a purpose-built centre specializing in state of the art microscopic imaging of cells and tissue, as well as sophisticated behavioural analysis of laboratory rodents. Project Overview The Regeneration Unit in Neurobiology (RUN) Core...
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Regulation of endosomal membrane trafficking by C9ORF72 in ALS
https://braincanada.ca/funded-grants/regulation-of-endosomal-membrane-trafficking-by-c9orf72-in-alsDr. Peter McPherson, professor at the Montreal Neurological Institute, McGill University will receive one year of support to work on the connection between the most prominent known cause of ALS, a mutation in a gene called C9ORF72, and a previously unrelated critical cellular function called...
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Regulation of the stress granule proteome and transcriptome by TDP-43 in ALS: biomarkers and therapeutic targets
https://braincanada.ca/funded-grants/regulation-of-the-stress-granule-proteome-and-transcriptome-by-tdp-43-in-als-biomarkers-and-therapeutic-targetsWhen cells are under stress, one of the reactions is to form tiny clumps called stress granules that protect important genetic information while protective mechanisms kick in. Project Overview When cells are under stress, one of the reactions is to form tiny clumps called stress granules that...
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Relating hippocampal pathways to human learning
https://braincanada.ca/funded-grants/relating-hippocampal-pathways-to-human-learningThe human experience is marked by constant learning. Project Overview The human experience is marked by constant learning. Moments of contention, when new experiences conflict with prior knowledge, often lead to the most meaningful learning. How do we successfully navigate these moments and gain...
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Relational end-of-life care for people living with dementia: Innovating education and supporting practice change
https://braincanada.ca/funded-grants/relational-end-of-life-care-for-people-living-with-dementia-innovating-education-and-supporting-practice-change“Dementia is now recognised as a terminal illness and a leading cause of death globally. People living with dementia (PLwD) in Canada suffer painful, undignified, and inhumane end-of-life (EOL) experiences. Project Overview “Dementia is now recognised as a terminal illness and a leading cause of...
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Relevance of stress granule dynamics to ALS pathogenesis in vivo
https://braincanada.ca/funded-grants/relevance-of-stress-granule-dynamics-to-als-pathogenesis-in-vivoAmyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective treatment. Project Overview Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective...
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Remote ischemic conditioning to mitigate neurodegeneration in Alzheimer Disease
https://braincanada.ca/funded-grants/remote-ischemic-conditioning-to-mitigate-neurodegeneration-in-alzheimer-diseaseWe need new ways to treat Alzheimer’s Disease (AD). People with AD are keen to try non-drug therapies but none are approved for treating AD. Remote ischemic conditioning (RIC) is a non-drug therapy that involves inflating and deflating blood pressure cuffs repeatedly in the arm or leg. Project...
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Remote Ischemic Preconditioning to promote CNS remyelination
https://braincanada.ca/funded-grants/remote-ischemic-preconditioning-to-promote-cns-remyelinationIn Multiple Sclerosis (MS), new brain lesions appear because of inflammation and loss of myelin (the structure covering nerves). Project Overview In Multiple Sclerosis (MS), new brain lesions appear because of inflammation and loss of myelin (the structure covering nerves). MS treatments stop...