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The blood-brain barrier (BBB) plays an essential role in protecting the brain from blood-borne diseases. Project Overview The blood-brain barrier (BBB) plays an essential role in protecting the brain from blood-borne diseases. However, it blocks otherwise effective medicine from reaching the brain....

Mutations within exon 1 of the huntingtin (HTT) protein promote its aggregation and accumulation in the brain and periphery, ultimately driving neuronal dysfunction and the clinical manifestation of Huntington’s disease (HD). Although HTT is a large protein composed of more than 3,000 amino acids,...

Tammy Moore, Chief Executive Officer, ALS Canada, participating in the Ice Bucket Challenge. Remember the Ice Bucket Challenge? The frisson of being challenged. The chill of water cascading down a body. The issuing of a summons to a friend or family. All for a noble cause: to promote aware­ness and...

In 97 per cent of ALS cases and nearly half of cases of frontotemporal dementia, the TDP-43 protein is misplaced to an area outside the cell nucleus of the motor neuron called the cytoplasm. Project Overview In 97 per cent of ALS cases and nearly half of cases of frontotemporal dementia, the TDP-43...

In 2021 we reported on the progress of Dr. Mari DeMarco’s IMPACT-AD project funded in part by Brain Canada, which was evaluating the implementation of a comprehensive biomarker testing strategy for Alzheimer’s disease. Study confirms value of biomarker testing in dementia care Dr. Mari DeMarco and...

Each year, over 1,500 Canadians sustain an acute spinal cord injury (SCI), and join close to 40,000 across our nation living with one of the most physically and psychologically devastating of injuries. Project Overview Each year, over 1,500 Canadians sustain an acute spinal cord injury (SCI), and...

Moving neuroscience research from the lab and turning it into a product is extremely challenging. Even the most groundbreaking technologies may never improve a patient’s life if the commercialization path is not successfully navigated. Project Overview Moving neuroscience research from the lab and...

Heart disease and brain health conditions including stroke are among the leading causes of death and disability in Canada and around the world. Earlier this year, Brain Canada, the CIHR Institute of Circulatory and Respiratory Health, and Heart & Stroke launched the inaugural Personnel Awards for...

Most strokes occur from clots blocking vessels that supply blood flow to the brain. Project Overview Most strokes occur from clots blocking vessels that supply blood flow to the brain. A large blockage in one of the main brain vessels is identified in up to 1/3 of patients presenting with stroke....

The human brain is one of the most complex structures in the universe, and we still know remarkably little about it. Across Canada, a new generation of scientists is working to change that. Brain Canada’s new podcast, Bold Minds: Future Leaders in Canadian Brain Research, brings their stories to...