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Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in humans. Project Overview Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in humans. The disease is caused by the degeneration of motor neurons that innervate the voluntary...

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly Project...

The brain cells in Alzheimer’s disease patients differ extensively from healthy brain cells at the molecular level: there are hundreds of genes that are normally active in the brain, but become inactive in Alzheimer’s. Project Overview The brain cells in Alzheimer’s disease patients differ...

Infants born early (preterm) are at risk for brain injury and long term neurodevelopmental challenges, including delays in walking, language development, and school-aged cognitive performance. Project Overview Infants born early (preterm) are at risk for brain injury and long term...

Kari Hoffman speaking at the 2018 Brain Canada AGM. The project In 2014, Kari Hoffman and her team were awarded a team grant to investigate the use of deep brain stimulation (DBS) as a potential treatment method to improve the function of the memory circuits impaired in AD and TLE. The...

Epilepsy is a debilitating disease affecting 1% of the world’s population. Project Overview Epilepsy is a debilitating disease affecting 1% of the world’s population. It is characterized by an enduring propensity to recurring seizures. One of the cornerstones of the diagnosis and management of...

While significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt ALS disease progression has remained elusive. Project Overview While significant efforts have been made worldwide, the development of an effective therapy to significantly slow...

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). Project Overview Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43...

Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with the brain and spinal cord. Project Overview Amyotrophic lateral sclerosis (ALS) is a nervous system disease that affects nerve cells (motor neurons) connecting muscle with...

We discovered that approximately one fifth of people with the deadly brain tumour glioblastoma show age-related genetic changes in their blood cells called ‘clonal hematopoiesis’, or CHIP. Project Overview We discovered that approximately one fifth of people with the deadly brain tumour...