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Gamma oscillations (GO) are electrical signals detected in the brain that are essential for memory and cognition. Project Overview Gamma oscillations (GO) are electrical signals detected in the brain that are essential for memory and cognition. GO are a product of the activity of a subpopulation of...

In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be aggressive and hard to treat. Project Overview In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be...

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in humans. Project Overview Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in humans. The disease is caused by the degeneration of motor neurons that innervate the voluntary...

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly Project...

Alzheimer’s disease (AD) affects nearly one million Canadians and remains without a cure. Although most research has focused on the build-up of abnormal proteins such as amyloid and tau, we now know that inflammation in the brain’s immune system plays a major role in how the disease starts and...

The brain cells in Alzheimer’s disease patients differ extensively from healthy brain cells at the molecular level: there are hundreds of genes that are normally active in the brain, but become inactive in Alzheimer’s. Project Overview The brain cells in Alzheimer’s disease patients differ...

Infants born early (preterm) are at risk for brain injury and long term neurodevelopmental challenges, including delays in walking, language development, and school-aged cognitive performance. Project Overview Infants born early (preterm) are at risk for brain injury and long term...

Kari Hoffman speaking at the 2018 Brain Canada AGM. The project In 2014, Kari Hoffman and her team were awarded a team grant to investigate the use of deep brain stimulation (DBS) as a potential treatment method to improve the function of the memory circuits impaired in AD and TLE. The...

Epilepsy is a debilitating disease affecting 1% of the world’s population. Project Overview Epilepsy is a debilitating disease affecting 1% of the world’s population. It is characterized by an enduring propensity to recurring seizures. One of the cornerstones of the diagnosis and management of...

While significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt ALS disease progression has remained elusive. Project Overview While significant efforts have been made worldwide, the development of an effective therapy to significantly slow...